Method of diagnosis of complement-mediated thrombotic microangiopathies

ABSTRACT

A method for identifying a patient&#39;s risk for developing complement-mediated thrombic microangiopathy is described. A sample of genetic material is obtained from a patient. The genetic material is amplified using primers specific for complement-mediated thrombic microangiopathy. After amplification, the genetic sequence of the amplicon is determined. The genetic sequence of the amplicon is compared to a reference sequence, and variations are identified between the sample amplicon and the reference sequence. A variation between the sample amplicon and the reference sequence is indicative of a risk for the patient for developing complement-mediated thrombic microangiopathy.

CROSS-REFERENCE TO RELATED APPLICATIONS

The present application claims the benefit of U.S. Provisional Patent Application No. 61/972,568 titled “Method for Diagnosis of Complement-Mediated Thrombotic Microangiopathies,” filed on Mar. 31, 2014, the contents of which are incorporated in this disclosure by reference in their entirety.

BACKGROUND

Thrombotic microangiopathy (TMA) is a disease that is caused by injury to endothelial cells that results in thrombosis in capillaries and arterioles. One of the categories of thrombotic microangiopathy is complement-mediated. Complement-mediated thrombotic microangiopathy (CMTM) is also known as atypical hemolytic-uremic syndrome (aHUS), complement-mediated hemolytic uremic syndrome and thrombotic microangiopathies of unknown etiologies. aHUS occurs when the body's overactive complement system attacks the cells that line blood vessels in the kidneys, causing inflammation and the formation of abnormal clots. aHUS is a life threatening, progressive, genetic disease that is characterized by three major features: microangiopatic hemolytic anemia (MAHA), thrombocytopenia and kidney injury, which can lead to kidney damage, kidney failure and end-stage renal disease. In addition, a patient's central nervous system may become involved, and gastrointestinal symptoms may also be present.

Fifty percent of patients diagnosed with aHUS will die, develop end-stage renal disease or suffer permanent kidney injury within one year after diagnosis despite plasma exchange or plasma infusion therapy. aHUS is considered a rare disease (1 in 500,000 in the general population of the United States). However, some reports have cited a prevalence as high as 1 in 150,000 in certain pediatric populations.

Development of aHUS occurs through a combination of environmental and genetic factors. aHUS most frequently occurs following a triggering event such as organ transplantation, pregnancy, malignant hypertension, autoimmune disorders, sepsis, or malignancy. The genes associated with aHUS regulate the complement system, which provides the instructions for making proteins involved in the body's immune response. The proteins destroy bacteria and viruses, trigger inflammation, and remove debris from cells and tissues. The complement system must be carefully regulated so that it only targets unwanted material and does not attack the body's healthy cells. The regulatory proteins associated with aHUS protect healthy cells by preventing activation of the complement system when it is not needed.

Mutations in at least seven genes appear to be associated with an increase in the risk of developing aHUS. The most common genetic mutation is found in the complement factor H (CFH) gene. Other genes involved include the Membrane cofactor protein (CD46), Complement factor 1 (CF1), Complement component 3 (C3), Complement factor B (CFB), Complement factor H-related proteins including CFHR1, CFHR3, CFHR4, CFHR5, Thrombomodulin (THBD), Plasminogen (PLG), and Diacyl glycerol kinase (DGKE).

As a thrombotic microangiopathy, aHUS presents with clinical features that are nearly identical to thrombotic thrombocytopenic purpura and hemolytic uremic syndrome, making immediate laboratory differentiation essential.

Current genetic methods for confirming a clinical diagnoses of CMTM or aHUS takes at least 28 days. However, since aHUS is a progressive disease, a faster turnaround time is required for faster patient diagnosis and management.

Therefore, there is a need for an improved method to rapidly identify mutations, polymorphisms and other variants of genes involved with CMTM in order to identify, diagnosis, and assess the risk of an individual in developing CMTM.

SUMMARY

According to one embodiment of the present invention, there is provided a method of identifying a patient's risk for developing complement-mediated thrombic microangiopathy, where the method contains the steps of: obtaining a sample of genetic material from a patient; amplification of the sample of genetic material using primers specific for complement-mediated thrombic microangiopathy; determining the genetic sequence of the amplified genetic material of step (b); comparing the sequence of the amplified genetic material with a normal reference sequence; and identifying variations between the sample amplified genetic material and the normal reference sequence. A variation between the sample amplified genetic material and the normal reference sequence is indicative of a risk for the patient for developing complement-mediated thrombic microangiopathy. The variation between the sample amplified genetic material and the normal reference sequence can be a mutation, a polymorphism, a deletion or the like. It is contemplated that at least twelve genes are amplified in the sample of genetic material. The twelve genes can include Membrane cofactor protein (CD46), Complement factor 1 (CF1), Complement component 3 (C3), Complement factor B (CFB), Complement factor H-related proteins including CFHR1, CFHR3, CFHR4, CFHR5, Thrombomodulin (THBD), Plasminogen (PLG), and Diacyl glycerol kinase (DGKE). The method can indicate a risk of the patent's developing aHUS. The method can be performed so that the risk for the patient for developing complement-mediated thrombic microangiopathy is identified within 48 hours or 5 days from receipt of the sample of genetic material from the patient.

According to another embodiment, a method for diagnosing complement-mediated thrombic microangiopathy in a patient by analyzing a patient's DNA sample for the presence or absence of variations in the patient's DNA sample is described. The method includes analysis of the DNA sequence of the genes comprising CFH, MCP, CFI, C3, CFB, CFHR1, CFHR3, CFHR4, CFHR5, THBD, PLG, and DGKE. If one or more variations in the genes comprising CFH, MCP, CFI, C3, CFB, CFHR1, CFHR3, CFHR4, CFHR5, THBD, PLG, and DGKE is detected, the patient is diagnosed with complement-mediated thrombic microangiopathy. The variation in the patient's DNA sample can be a mutation, a polymorphism or a deletion. The diagnosis is made within 48 hours or 5 days from receipt of the sample of genetic material from the patient.

In another embodiment, a method for determining the risk of complement-mediated thrombic microangiopathy is described. The method includes assessing a DNA sequence from 12 genes consisting of CFH, CD46, CFI, C3, CFB, CFHR1, CFHR3, CFHR4, CFHR5, THBD, PLG, and DGKE in the patient's DNA sample by amplifying the DNA sequences. The DNA sequences are selected from the group comprising SEQ ID NO. 1 through SEQ ID NO. 1014. The method also includes comparing the amplified DNA sequences with DNA sequences from a normal control subject. Any variations in the patient's DNA sequence as compared to the normal control subject indicates that the subject has a risk of complement-mediated thrombic microangiopathy. The variation in the subject's DNA sample can be a mutation, a polymorphism, or a deletion. The determination can be made within 48 hours, or 5 days, from receipt of the sample of genetic material from the patient.

DESCRIPTION

According to one embodiment of the present invention, there is provided a method for rapid detection of mutations, deletions and polymorphisms that have been previously reported as associated with complement-mediated TMAs. The time for diagnosing or determining the patient's risk of developing a complement-mediated TMA using the method of the present invention can be as early as 48 hours after receipt of the patient's sample. The method of the present invention can also be used to diagnose or determine complement-mediated TMA within 5 days after receipt of the patient's sample. The method involves analysis of 12 genes, including: Complement factor H (CFH), Membrane cofactor protein (CD46), Complement factor 1 (CF1), Complement component 3 (C3), Complement factor B (CFB), Complement factor H-related proteins including CFHR1, CFHR3, CFHR4, CFHR5, Thrombomodulin (THBD), Plasminogen (PLG), and Diacyl glycerol kinase (DGKE), referred to herein as the “genes of interest.”

As used in this disclosure, except where the context requires otherwise, the term “comprise” and variations of the term, such as “comprising,” “comprises” and “comprised” are not intended to exclude other additives, components, integers or steps. Thus, throughout this specification, unless the context requires otherwise, the words “comprise,” “comprising” and the like, are to be construed in an inclusive sense as opposed to an exclusive sense, that is to say, in the sense of “including, but not limited to.”

As used in this disclosure, except where the context requires otherwise, the method steps disclosed and shown are not intended to be limiting nor are they intended to indicate that each step is essential to the method or that each step must occur in the order disclosed.

As used herein, “sample” refers to any sample that can be from or derived a human patient, e.g., bodily fluids (blood, saliva, urine etc.), biopsy, tissue, and/or waste from the patient. Thus, tissue biopsies, stool, sputum, saliva, blood, lymph, tears, sweat, urine, vaginal secretions, or the like can be used in the method, as can essentially any tissue of interest that contains the appropriate nucleic acids. The sample may be in a form taken directly from the patient. Preferably, the sample may be at least partially purified to remove at least some non-nucleic acid material.

The term “DNA sequence” as used herein refers to chromosomal sequence as well as to cDNA sequence.

The term “amplifying” in the context of nucleic acid amplification is any process whereby additional copies of a selected nucleic acid (or a transcribed form thereof) are produced. Typical amplification methods include various polymerase based replication methods, including the polymerase chain reaction (PCR), ligase mediated methods such as the ligase chain reaction (LCR) and RNA polymerase based amplification (e.g., by transcription) methods.

An “amplicon” is an amplified nucleic acid, e.g., a nucleic acid that is produced by amplifying a template nucleic acid by any available amplification method (e.g., PCR, LCR, transcription, or the like).

A “gene” is one or more sequence(s) of nucleotides in a genome that together encode one or more expressed molecules, e.g., an RNA. The gene can include coding sequences that are transcribed into RNA which may then be translated into a polypeptide sequence, and can include associated structural or regulatory sequences that aid in replication or expression of the gene.

A “set” or “pool” of primers or amplicons refers to a collection or group of primers or amplicons, or the data derived therefrom, used for a common purpose, e.g., identifying an individual with a specified genotype (e.g., risk of developing aHUS). Frequently, data corresponding to the primers or amplicons, or derived from their use, is stored in an electronic medium.

A set of oligonucleotide nucleic acid sequences, or primers, have been identified that facilitates the rapid identification of mutations, polymorphisms, and other variants of Complement-mediated thrombotic microangiopathy (CMTM). This set of oligonucleotides detects sequences that are indicative of the risk that an individual has for developing CMTM.

The primers are used to amplify certain genes involved with CMTM, including CFH, CD46, CF1, C3, CFB, CFHR1, CFHR3, CFHR4, CFHR5, THBD, PLG, and DGKE. The list of primers is set forth in Appendix A.

The DNA used in the method of the invention can be extracted from whole blood, extracted from a buccal swab, or it can be from previously extracted genomic DNA samples. Preferably, the DNA is extracted from whole blood using known techniques. Prior to analysis, extracted DNA can be stored for one month at room temperature or 2-8° C. For longer storage of up to 2 years, DNA can be stored frozen at <−20° C. to minimize the degradation of nucleic acid.

After extraction, the DNA sample is measured and assessed for purity. 30 ng of genomic DNA, at a minimum concentration of 1.7 ng/μL, is required for analysis. The concentration of purified DNA should preferably be adjusted to 2 ng/μL to 25 ng/μL prior to analysis. Optimal DNA purity is an absorbance ratio (A₂₆₀/A₂₈₀) of 1.80 or greater (typical range is 1.60 to 2.00).

The extracted sample DNA is then amplified. A well-known amplification method is the polymerase chain reaction (PCR). In PCR, a characteristic piece of the particular nucleotide sequence of interest is amplified with specific primers. If the primer finds its target site, a sequence of the genetic material undergoes a million-fold proliferation.

During the PCR process, the DNA generated is used as a template for replication. This sets in motion a chain reaction in which the DNA template is exponentially amplified. PCR can amplify a single or few copies of a piece of DNA by several orders of magnitude, generating millions or more copies of the DNA piece. PCR can be extensively modified to perform a wide array of genetic manipulations, as known by one of skill in the art.

In the method described herein, one primer pool aliquot is used per sample. The primer pool aliquot contains a minimum of 93 primer sets directed towards the 12 genes of interest, as listed in Appendix A.

Following standard techniques, the amplified sequences, or amplicons, are purified and a library is made with the purified amplicons. The library contains multiple sequences from different areas of the 12 genes of interest. The library made from the amplicons is then amplified and sequenced.

The DNA sequence of the library may be determined by any suitable method, such as multiplex sequencing, as is known by one of skill in the art. For example, the DNA sequence may be determined by available method, including Sanger sequencing (chain termination), pH sequencing, pyrosequencing, sequencing-by-hybridization, sequencing-by-ligation, etc. Exemplary sequencing systems include 454 pyrosequencing (454 Life Sciences), Illumina (Solexa) sequencing, SOLiD (Applied Biosystems), and Ion Torrent Systems' pH sequencing system.

After sequencing, the DNA sequence of the library is mapped with one or more reference sequences to identify sequence variants. For example, the base reads are mapped against a reference sequence, which in various embodiments is presumed to be a “normal” non-disease sequence. The Human genome (Hg19) sequence is generally used as the reference sequence. A number of computerized mapping applications are known, and include GSMAPPER, ELAND, MOSAIK, and MAQ. Various other alignment tools are known, and could also be implemented to map the DNA sequence of the amplicon library.

Based on the sequence alignments and mapping results, sequence variants are identified based upon available information including for example, information from human mutational databases and other reference databases. Furthermore, any sequence variations, including aHUS-associated mutations, disease-associated polymorphisms, benign polymorphisms and other known variants of undetermined significance can be determined to be homozygous or heterozygous. Any variations in the gene analyzed as compared to the normal control gene can be classified as pathogenic, predicted pathogenic, uncertain, predicted benign or benign, as recommended by the American College of Medical Genetics (ACMG).

EXAMPLES Example 1

The DNA was extracted from the whole blood of Patient 1 using known procedures. The extracted sample DNA was then amplified. One primer pool aliquot was used per sample. The primer pool aliquot contained 95 sets of forward and reverse primers as set forth in Appendix A. In the present example, the twelve target genes were amplified and analyzed.

Following standard techniques, the sample DNA was amplified, and the amplicons were purified. A library was then made with the purified amplicons. The library was amplified and sequenced. After sequencing, the sequence of the amplicon from the sample was compared to a reference sequence comprising the Human genome (Hg19) sequence.

In this example, a heterozygous mutation in the CFH gene was identified. The mutation was a nonsense mutation, Try957Stop, which created a premature stop codon that prevents the rest of the protein from being translated and will likely result in a functional defect. Additionally, the mutation falls within the SCR domain, which is considered to be a hotspot region for aHUS-associated mutations. Mutations in the SCR domain generally result in a failure to regulate complement at cell surfaces. Renal and/or liver transplantation may have an increased failure rate in this patient.

Example 2

The DNA was extracted from the whole blood of Patient 2 using known procedures. The extracted sample DNA was then amplified. One primer pool aliquot was used per sample. In the present example, the twelve target genes were amplified and analyzed.

Following standard techniques, the sample DNA was amplified using forward and reverse primers as set forth in Appendix A, and the amplicons were purified. A library was then made with the purified amplicons. The library was amplified and sequenced. After sequencing, the sequence of the amplicon from the sample was compared to a reference sequence comprising the Hg19 sequence.

In this example, a common polymorphism (c.184G>A, p.Val62Ile, rs800292) was detected in the CFH gene from Patient 2. This polymorphism is present in about 43% of the general population. The polymorphism was detected in detected in 48% of the total reads, indicating this donor is heterozygous for this variant. This polymorphism does not correlate with aHUS disease.

Although the present invention has been discussed in considerable detail with reference to certain preferred embodiments, other embodiments are possible. Therefore, the scope of the appended claims should not be limited to the description of preferred embodiments contained in this disclosure. All references cited herein are incorporated by reference in their entirety.

APPENDIX A SEQ SEQ ID ID Gene Chro- Amplicon Insert Insert Amplicon NO Forward Primer NO Reverse Primer Symbol mosome Start Start Stop Stop   1 CTCCAAGAAGAAATACAGAAATTCTGACAG  508 GACTGGCAATAGTGATATAATTCAGGCATA CFH chr1 196642122 1.97E+08 1.97E+08 1.97E+08   2 CCATGTTCACAACCACCTCAGA  509 TAACCTTCACACTGAGGTGGAGAA CFH-896- chr1 196706612 1.97E+08 1.97E+08 1.97E+08 900del5aa   3 TCTCATGGTGTTGTAGCTCACATG  510 TTGGTACCACTTACACTTTGAATGAAGAA CFH chr1 196709777 1.97E+08 1.97E+08 1.97E+08   4 CATAAGGTACAGATGTAGAGGAAAAGAAGG  511 ACCTGCCTTATTCAGTAGCATTTGTAATAA CFH chr1 196697566 1.97E+08 1.97E+08 1.97E+08   5 GCAATGGAACCAGATCGGGAAT  512 TGCTGATATTCCTTAGAATGAACGATGTTT CFH chr1 196646658 1.97E+08 1.97E+08 1.97E+08   6 ATTTGTAACTGTTATCAGTTGATTTGCTACT  513 GGCTCCTACATTGATAACGTACTCTC CFH chr1 196712506 1.97E+08 1.97E+08 1.97E+08   7 CTATGGAGATTCAGTGGAATTCAATTGC  514 CTGGAAATGTTGAGGCATATCTGTAAATTT CFH chr1 196695963 1.97E+08 1.97E+08 1.97E+08   8 ATGCTAAGGACAAATAAATAACACCCACT  515 CGTGATTTCATCTCCAGTTCTGTGTTTAA CFH chr1 196654088 1.97E+08 1.97E+08 1.97E+08   9 GTACCGTTGCCAGTCCTTCTAT  516 GACAGGAAAGATTTTGACTGAATGAAACTT CFHR5 chr1 196973884 1.97E+08 1.97E+08 1.97E+08  10 CGTCTGTCCCTCCCTATCAACA  517 CTTGTGGAAGGAAGAGTCAGTATCAATAAA CFHR5 chr1 196965205 1.97E+08 1.97E+08 1.97E+08  11 CAAACTAGGATATGTAACAGCAGATGGT  518 CCCACAAAAAGACTAAAGTTAGTAAACTTTT CFH chr1 196682958 1.97E+08 1.97E+08 1.97E+08  12 GCCCAATCTTTGCAAAGGGAAT  519 GCCCGTGATACACCAAGAAATG CPAMD1 chr19   6692813  6692835  6692937  6692959  13 GTAGGAAAGGCTCCCACCTTT  520 GAACCGAGGACACCTAGTAGGT CPAMD1 chr19   6707459  6707480  6707586  6707608  14 GTCTGCTCCGATCTCTGCTTT  521 TCGTGCTGAATAAGAAGAACAAACTGA CPAMD1 chr19   6709566  6709587  6709705  6709732  15 TTTTTAACATCTTGCATTCCATTCCTTGT  522 CCATTTTCGACTACTGGAAATCGACAT CD46 chr1 207940240 2.08E+08 2.08E+08 2.08E+08  16 AGAGGAAGAAGATTAATGTTCTAGAGAACG  523 TGTGTCACATTCACGGTAATTAATCTCA CFH chr1 196644895 1.97E+08 1.97E+08 1.97E+08  17 TTTTTAAAATTTTTATTGCAAGTGAAACCTTGT  524 CCATCCATCTTGTGTGCAATGAATG CFH chr1 196658527 1.97E+08 1.97E+08 1.97E+08  18 AGGAAAATGTTATTTTCCTTATTTGGAAAATGG  525 TCATCTATGTTACTTAGAAAGACATGAACATGC CFH chr1 196659190 1.97E+08 1.97E+08 1.97E+08  19 GGGACATTACTTCATTCCCGTTGT  526 AAATATCAGACTCATCACAGAGATTTTTCCA CFH chr1 196714988 1.97E+08 1.97E+08 1.97E+08  20 AGAGAAAGATGGGAGAGGGTATACC  527 AGAGGGACCATCTCCTCTTGTC CPAMD1 chr19   6684465  6684490  6684716  6684738  21 CTCCTCCTCTTACCGTACTCCTT  528 CTTGTCTTGGGACATTCCGGAA CPAMD1 chr19   6714163  6714186  6714370  6714392  22 GCTTGTGGTTGACGGTGAAGAT  529 ACAGGGAGTTCAAGTCAGAAAAGG CPAMD1 chr19   6718142  6718164  6718389  6718413  23 TTCTCACTGGACAGCACTAGTTTTT  530 TCTCACATCCGTGGAATGACAAG CPAMD1 chr19   6719270  6719295  6719440  6719463  24 CCTCAGAACCTCAGAACCTCAAC  531 TGTCTAGCTTTCAAAGTTCACCAATACTTT CPAMD1 chr19   6679981  6680004  6680223  6680253  25 GGGTTGCACTGTGATTCCAGA  532 CAACTGGCCTGCTCTGTTCTA CPAMD1 chr19   6702380  6702401  6702614  6702635  26 CCCACATGAGGTAGTGTTTCTTCT  533 AGCTGTCCAATGACTTTGACGA CPAMD1 chr19   6678196  6678220  6678417  6678439  27 CCTGAACTTCAGCCATGCATCT  534 TGATCCTTACTAACGTGACAGCAATG CPAMD1 chr19   6686706  6686728  6686950  6686976  28 CTTCCAGGGTGACCTTGTCATC  535 GGTCTGAGCAAGCCACACTTAC CPAMD1 chr19   6679174  6679196  6679367  6679389  29 CCACGCAGGAGTCCTTGAC  536 CCCAGATCATGAACAAGGGCA CPAMD1 chr19   6710654  6710673  6710840  6710861  30 CATGAGGTCAAAGGGCATTCCT  537 GAGGGAGGAGGTCTAATCCTGAG CPAMD1 chr19   6712518  6712540  6712674  6712697  31 TCCAGGTAGATGATGAGGGTGTT  538 AGGATGCCACTATGTCTATATTGGACAT CPAMD1 chr19   6681955  6681978  6682198  6682226  32 CCCGAGCCATCCTCAATCT  539 GGGAGATCCCATTCTCCAGG CPAMD1 chr19   6713309  6713328  6713557  6713577  33 CAAGGCTTGGAACACCATGAAG  540 CTCTAGTAGGTTCTAGGCCACATTTTG CPAMD1 chr19   6685130  6685152  6685254  6685281  34 GAACAGGTGAGGTTTCAAGTAGGA  541 ACATCATCGGGAAGGACACTTG CPAMD1 chr19   6677751  6677775  6678004  6678026  35 TCTTTAGCGGCACGATGACATAT  542 GGAAATCCGAGCCGTTCTCTAC CPAMD1 chr19   6697437  6697460  6697689  6697711  36 GGTTGTCTGAAGGCCAGCT  543 CACCTCCTCGTTCTGATCCC CPAMD1 chr19   6693467  6693486  6693659  6693679  37 GGAAGAGAAAGGTGCGGGTTAA  544 GGGTAAATGACCTGGGTTTAGTGA CPAMD1 chr19   6696288  6696310  6696532  6696556  38 GCAGGAGGAAGTTGACGTTGAG  545 CAATTCCCAGGTCTCAGGGATTC CPAMD1 chr19   6711044  6711066  6711261  6711284  39 CCCTCAAACTACTGTAGTGTAGAAAAGA  546 GTGTAAAGGGTGTAAAGGAGGCAA CD46 chr1 207932873 2.08E+08 2.08E+08 2.08E+08  40 ATTTTATCCCACTTGTTATGCTACTCGT  547 GCCAATATCTCTTTGCTCAGGTTATTGATA CD46 chr1 207963513 2.08E+08 2.08E+08 2.08E+08  41 TTTTTCCTAGGATATCCTAAACCTGAGGA  548 CCCTACCAAGGATCCTATGTTTGG CD46 chr1 207956626 2.08E+08 2.08E+08 2.08E+08  42 GTCATTCAGGTTTAGTAGCTTCTTCCT  549 TAAGTGAACATCACCAGAAATTTGAAGGA CD46 chr1 207940987 2.08E+08 2.08E+08 2.08E+08  43 GCCAAGGGCCTTTCTGTTTTT  550 GGCAAGAGGAGGTATATAGAAGTATCCTTT CD46 chr1 207930248 2.08E+08 2.08E+08 2.08E+08  44 GCTCCAGCTGCTTTTGCATATG  551 GTTCAAAGCTCACTTGACATTAAGTACATT CFI chr4 110685736 1.11E+08 1.11E+08 1.11E+08  45 GACAGAATCTATATTATTGCCTCTGTGACT  552 CGCTGATGTGGTTTGTTATACACAGA CFI chr4 110682548 1.11E+08 1.11E+08 1.11E+08  46 TAGCGGATGAAAATATGAGGAGATGAAC  553 CATTCCAAGCCAGTATCAATGCA CFI chr4 110681252 1.11E+08 1.11E+08 1.11E+08  47 GTGCTAGGAAATTAGCTCCTATACATTTCT  554 ACTACAATGCAGGCACTTACCAAAA CFI chr4 110667292 1.11E+08 1.11E+08 1.11E+08  48 TTTAGGCTGTTTCTGGGCAGTT  555 TGTGGCATAGATAATCAAGAAGTGTGTT CFI chr4 110670605 1.11E+08 1.11E+08 1.11E+08  49 ATTTGTTGCTGACTATAGAGTGGCAT  556 TTTCAAAAGAATACCTGGAGTGGAAAAGA CFI chr4 110722925 1.11E+08 1.11E+08 1.11E+08  50 CCGTTTTATTTCCATTAAATGGAACTCTT  557 GTGTTTACACCAAAGTGGCCAATTAT CFI chr4 110661981 1.11E+08 1.11E+08 1.11E+08  51 GGAATGTGTTCCTTTCCTTTTGTGAAAA  558 TCTTTAAATAATTAGCAAAACTGAGAGAGTGGT CFHR5 chr1 196953089 1.97E+08 1.97E+08 1.97E+08  52 TTTTTAAGTTGATGGTCCAACTGTGTT  559 ATCAACAGCTTAGAATTGGATTGGGA DGKE chr17  54939400 54939427 54939645 54939671  53 CTTTTCATCAGCATCTAGTCTACCATAAGG  560 AAGTCTTCATAATCCAGAGACCACCTA DGKE chr17  54935814 54935844 54936060 54936087  54 CTAGGGACAAGAAAAGTACATTCCACA  561 AGTCTTCACTTGTTAACCAATTATGGCTAA DGKE chr17  54926052 54926079 54926252 54926282  55 AGGGTGCCTGGCATATTGTTAAA  562 GTACAGAGTTGTAGGGCTTTGATAGG DGKE chr17  54925142 54925165 54925306 54925332  56 TGCATATATTTTATTTGCCAAATGTTATGGT  563 TTCTCCAAAATCACATTTTTCATTCTTTAAACT DGKE chr17  54921239 54921270 54921425 54921458  57 ACCAGGTCTAGGTCTGGAGTTT  564 GGTGGTCACACCTGAAGAGAAA CFB chr6  31913885 31913907 31914138 31914160  58 AAATGGCCATAAGAGATGGTGGTT  565 GATCTGTAGAAAGTGGGAGGTGTT CFB chr6  31917997 31918021 31918227 31918251  59 TATCAGGTGAGAGCGTCCAGAT  566 GCCAGGCATCATCTCTTCCTATT CFB chr6  31918543 31918565 31918790 31918813  60 GAGGAGTGAGTCCCTATGCTGA  567 AGGCTCTGCCTACCTCGAATTA CFB chr6  31919211 31919233 31919464 31919486  61 GTTTTCGCACTCGTCGATGT  568 CTTCAGAGCCAACTGCGAGTA THBD chr20  23028800 23028820 23029014 23029035  62 GGGTTGGGAACGCAGAAGT  569 TCGGCTTACAGCTAATGTGCA THBD chr20  23029242 23029261 23029468 23029489  63 GAAGTGGAACTCGCAGAGGAA  570 GTTACGGGAGACAACAACACCA THBD chr20  23029628 23029649 23029789 23029811  64 AGAGTCCAATCCACCGAACTCT  571 CGGTTGAAAATCCTTGAATTTGCCA PLG chr6 161173232 1.61E+08 1.61E+08 1.61E+08  65 AATCTGTCTGCTAATACAGAAAAGAGAACA  572 GGTAGCTCTGTCCATCACCATG PLG chr6 161143306 1.61E+08 1.61E+08 1.61E+08  66 CTCAATGTTTGCTCTTGAAAAAGAGTCT  573 ACTGACACATGTTTTCTTTTGATTTCAAGA PLG chr6 161137596 1.61E+08 1.61E+08 1.61E+08  67 GTCATGACAATTAGACATTGACATTGATTT  574 AAATTTGTGAGTAAATTACTTGCCATCTGAATT PLG chr6 161127371 1.61E+08 1.61E+08 1.61E+08  68 GACTATGCTGTGCAGACCTTCA  575 CTCACAGACACAGAGGGACAACTT PLG chr6 161132038 1.61E+08 1.61E+08 1.61E+08  69 ATGGCACAGAGGTTACCTGAAG  576 CCCATAAAACCCAGACATAAAGCAAA PLG chr6 161160034 1.61E+08 1.61E+08 1.61E+08  70 TGTAAACCAGGATATGCAACAGCA  577 CATCTCAAAGAGAGGAACGAAGTTGA CFHR3 chr1 196757437 1.97E+08 1.97E+08 1.97E+08  71 GTGCACCGCCTGTTTCTT  578 CTTGCTCTTGCGGAAGATGTC DGKE chr17  54912110 54912129 54912312 54912333  72 GTATCCCTGCCTTTAGCCAGTTTA  579 CCAAACACATAGACATCTGAGGGATA CFB chr6  31916953 31916977 31917186 31917212  73 GGAATGCGCTGTTTCTCAGTGA  580 GCAGTGGAAAGAGATCTCATCACTC CFB chr6  31914680 31914702 31914853 31914878  74 CCCAGGAAAATCTCCAGGTCCTA  581 CATATGTCACTAGACCATATCTTGGCTT CFB chr6  31915954 31915977 31916168 31916196  75 GCTTCAGTGCTTACCTCGATGT  582 GTAGGATGGAAGACCAGGATCTGA CFB chr6  31915087 31915109 31915323 31915347  76 CCCTAGCTTCATGGTAGTGCA  583 AGACATACAAAGCTAGATATTACATGAAGTTAC CFHR3 chr1 196743893 1.97E+08 1.97E+08 1.97E+08  77 GGATGCATTTTATTTGCTCATGAAAGAGA  584 CCGACACACTGCTTGAAATGATAGAAT CFHR3 chr1 196762381 1.97E+08 1.97E+08 1.97E+08  78 GTACATTATTTTTGGATGTTTATGCGATCT  585 CTTTCTCCGTACATGTAACTGTGGT CFHR3 chr1 196748803 1.97E+08 1.97E+08 1.97E+08  79 AAAGTGCTGTGTTTGTATTTGCCTTAT  586 AACTGATGAAGCTGGAGCATATACTG CFHR1 chr1 196799542 1.97E+08 1.97E+08 1.97E+08  80 GTAATTCTTCAGTTTTATGTTATTTTCCCAGCA  587 GTCCAAAATGATTTTGAAGGAGACACAAA CFHR1 chr1 196794575 1.97E+08 1.97E+08 1.97E+08  81 GATCCGTGTGTAATATCCCGAGAAATTA  588 CTAAAGTTCTGAATAAAGGTGTGCATTTTATGA CFHR1 chr1 196800925 1.97E+08 1.97E+08 1.97E+08  82 GACTGTGTTTCTTTCCTTTTGTGGAAAA  589 AGTATGTGGCAAAACCTATATTTAACCTGTAAA CFHR1 chr1 196795958 1.97E+08 1.97E+08 1.97E+08  83 CAAGAGTAATGGCATGCGGTTT  590 CACACTCATAGGAGGACTACATATATATGTACA CFHR4 chr1 196883661 1.97E+08 1.97E+08 1.97E+08  84 GCATTTTATTTGCTCATGAAAGGCAA  591 GGTATTCCACTATGCCTTCCCTACA CFHR4 chr1 196887276 1.97E+08 1.97E+08 1.97E+08  85 AATTCATTAACAAATGTTTCATTGTTTTGCC  592 AAACATGTAATTGAACCTGAAGAATTTCCATC CFHR4 chr1 196881754 1.97E+08 1.97E+08 1.97E+08  86 TTTATTCCTACAATGGGACTTTCTTAGTCG  593 TCTGTGGTGTTCCATAACTGCTTT CFHR4 chr1 196875907 1.97E+08 1.97E+08 1.97E+08  87 GCCAGCTAAGGTGCTTTGGTA  594 CATTCGGGCTTGCTCATAGG THBD chr20  23028329 23028350 23028582 23028602  88 TCAATTCATTAACAGATGTTTCATTGTTTCA  595 GAGGAAGATTCAGAAATGAATCCATTTTCAATT CFHR4 chr1 196874120 1.97E+08 1.97E+08 1.97E+08  89 GGTGCTGATTGTGAAAACATTGC  596 CAATTCTCACTGCACTCCCACTA CFH-C-257T chr1 196620770 1.97E+08 1.97E+08 1.97E+08 polymorphism  90 GTGGGAGTACTGCAACCTGAAAA  597 GTTTCTGCATCAGTGAGATTTTCCATG PLG chr6 161152160 1.61E+08 1.61E+08 1.61E+08  91 TGGTGCTACACGACAAATCCAA  598 CCAGAAGCAGTCTGCTCAGAAG PLG chr6 161155062 1.61E+08 1.61E+08 1.61E+08  92 TAGAGAGACATAGTGTGTGTGTGTCA  599 TCACTGTGGTTGTCATATTCTGAGC CFHR5 chr1 196971494 1.97E+08 1.97E+08 1.97E+08  93 AGCTGAATGAAAAACAAAACTATAAATGAGATG  600 AACTTGGGAAAAAGGGTTATAATCTTCTTCA CFHR5 chr1 196951909 1.97E+08 1.97E+08 1.97E+08  94 CCAAAAATAGAAGTGCAATATAAAGGCAA  601 GCCCGTTTATTATAAAATTAGGATTGCAAT CFHR5 chr1 196964729 1.97E+08 1.97E+08 1.97E+08  95 CTTCCCGCAAAAAGTGTATCTGC  602 AACACAGTTCTAGGGTAATAACCCATAAAAATT CFHR4 chr1 196876500 1.97E+08 1.97E+08 1.97E+08  96 ACACCATTCTTGATTGTTTAGGATGCT  603 GTCCCTTCATTAGAAATCTAGGATTGCA C630W chr1 196695453 1.97E+08 1.97E+08 1.97E+08  97 TGACTTCACATGGTTTAAGCTGAATGA  604 CCCAGTTTATGTCAAATCAGGAGATATCTT CFH-C564P chr1 196684765 1.97E+08 1.97E+08 1.97E+08  98 ACTCAGGGAACTCTTCTTGTTTGG  605 AAAACAGATACTAGTCACCATACTCAGGA CFH chr1 196670332 1.97E+08 1.97E+08 1.97E+08  99 TTTTTAGTGGCACAAATACAATTATGCC  606 GCACAAGAGAATATTAACCTCATTTGAAAGAAT CFH chr1 196705946 1.97E+08 1.97E+08 1.97E+08 100 CAATTCTTGGAAGAGGAGAACTGGA  607 GCCACTCAATTGTCAAGTTACAGAATACTT CFH chr1 196621173 1.97E+08 1.97E+08 1.97E+08 101 CAAATGGTGACTACTCACCTTTAAGGA  608 GCTTCCAACAGCCTTACTTTGTATATACAA CFH chr1 196654220 1.97E+08 1.97E+08 1.97E+08 102 ACCATTTCTTCTTTCAGATCCATGTGT  609 GCTACTTTTAGCATAGATGGATGTTTGAAG CFHR5 chr1 196977599 1.97E+08 1.97E+08 1.97E+08 103 AGTTTTGTGATGTTGCTTAAAAGCATCA  610 TCTTTCCCAGATAGCTTGAGTAATGTTTTT CFHR5 chr1 196967151 1.97E+08 1.97E+08 1.97E+08 104 CCCTTGCATCTTATTTTTATATAGCACACA  611 GGTGACCACCCAAATTGGTAACAT CFHR5 chr1 196963124 1.97E+08 1.97E+08 1.97E+08 105 CCAAAAATACACCATGGATTTCTGTATGA  612 CCCTTGTGATTATCAAGACCTTATGATCTT CFHR5 chr1 196952031 1.97E+08 1.97E+08 1.97E+08 106 ACCGCCACCTCAGATACCTAAT  613 GTGCAACAGATTAGTCATAAGTTCTTGTTT CFHR5 chr1 196971633 1.97E+08 1.97E+08 1.97E+08 107 ATCGCTATTTTAGAATCCATTACATGTATTGT  614 ATCCTTCTTCTCTCCCATGGGTAT CFH chr1 196710918 1.97E+08 1.97E+08 1.97E+08 108 CTCAAGAACCTGACATACTTGACGA  615 CTCCGAAGAGCCACTTTATCCTC CPAMD1 chr19   6714344  6714369  6714482  6714505 109 CACGGTCACGAACTTGTTGC  616 ATAATGGGCAGGCAAGGAGGGA CPAMD1 chr19   6718366  6718386  6718502  6718524 110 AGCAAAGCCAGTCATCATGGAT  617 AGAAGTCTCAGTGCCTGATCAGA CPAMD1 chr19   6682176  6682198  6682315  6682338 111 TTTTTGGTTTTCAGGTATCAATTGCTAGG  618 ACTAGATTCCCACTCTACATTGTATGAGAA CFH chr1 196645104 1.97E+08 1.97E+08 1.97E+08 112 CCCACTCCTACATAAAATATATTCCTTGCT  619 ACAGCTTTTACACCATATTCAAACACATTT CFH chr1 196642919 1.97E+08 1.97E+08 1.97E+08 113 CGTCAGGAAGTTACTGGGATCA  620 GGTGTAATCACTTATGTGCTCTCCTT CFH chr1 196658675 1.97E+08 1.97E+08 1.97E+08 114 CCCTCTGTATGACCCAATATCAACC  621 GCGATCAGGAACTAAGTGTACATCTATTTT CFH chr1 196694143 1.97E+08 1.97E+08 1.97E+08 115 AATCAATAAAGCTTTTTCTTCTTAGAATGGG  622 GCTTAAACCATGTGAAGTCATTTTTAGTTCT CFH chr1 196684629 1.97E+08 1.97E+08 1.97E+08 116 AGACAGATGAGTAAATATCCATCTGGTGA  623 CCATCAGTCATTTTATTTGCATTTGAAAAATCT CFH chr1 196712631 1.97E+08 1.97E+08 1.97E+08 117 TCTTGAGATGAGGTGGGATCTTAGG  624 CGGTCATCGCTGTGCATTAC CPAMD1 chr19   6694359  6694384  6694514  6694534 118 GCGCAGGAGAGAACCTCTCTAT  625 GCAGTCTCTAACCCAGGGAGAT CPAMD1 chr19   6712138  6712160  6712324  6712346 119 TCCAGGCTGGATAAGCTCTACATT  626 CTCCTTGATCCTTCAGTTTCTCCA CPAMD1 chr19   6680199  6680223  6680352  6680376 120 GGGTGTTCCTGCTCCCATTT  627 GGGCAGTGGGAAGGATTACG CPAMD1 chr19   6707632  6707652  6707879  6707899 121 TGGGAGAGGAGACACAATGTCA  628 CAGGGTTTACTGGGAAGCAAGA CPAMD1 chr19   6684670  6684692  6684922  6684944 122 TCTGCTCAATGGCCATGATGTAC  629 CAACTTTCTGCTTGGGAGAGAGA CPAMD1 chr19   6678394  6678417  6678553  6678576 123 CACTCTGAGCCTCCCTCCTTA  630 CCGAGCAGAAGACCTGGTG CPAMD1 chr19   6713092  6713113  6713242  6713261 124 GGGATGAAGTCGGTGGTGAT  631 AAGATCCGCTACTACACCTACCT CPAMD1 chr19   6710755  6710775  6710998  6711021 125 CCCTAAATCCCAGCCTCTTACAAT  632 TCTCTGGATCTCAGAGCCGATT CPAMD1 chr19   6692913  6692937  6693119  6693141 126 ACACCCAAATGCACCCTGAAT  633 GAGCCAGATAAAAAGCCAGCTC CPAMD1 chr19   6720425  6720446  6720676  6720698 127 GGCCTCAGTGTCTTCTCTAGGA  634 CTGGTAAGCAGCTCTACAACGT CPAMD1 chr19   6686051  6686073  6686255  6686277 128 CCCTCACCTGGCTCTTACCT  635 GGTGAAGGAGTACGGTAAGAGGA CPAMD1 chr19   6713960  6713980  6714167  6714190 129 GATGAGTTAAGTGCTCAAAAGATGTTAGC  636 GGTGGATTACGGAACAACAACGA CPAMD1 chr19   6690472  6690501  6690715  6690738 130 TTCTCTTCGTCTTGGCATTCGT  637 GAGGAGAAGAAACACTACCTCATGTG CPAMD1 chr19   6677959  6677981  6678198  6678224 131 CAGGGTCTAAGTCCCACTCCTT  638 TCTACCATCCGGAAAAGGAGGA CPAMD1 chr19   6679238  6679260  6679467  6679489 132 GCTCTTGGTTCTGCCGGTAATT  639 CGGAGTGGACTAAGAGCTGAGA CPAMD1 chr19   6697667  6697689  6697870  6697892 133 CGCCCTATCCTACCTCACTAAAC  640 GCTAGGGTGATCCTAAGGACAGT CPAMD1 chr19   6696518  6696541  6696745  6696768 134 CACTGGCCCTTACCTTACTCTG  641 CCAACCTTTCTGTCTTTCCACTCTAG CPAMD1 chr19   6709681  6709703  6709928  6709954 135 TGTTCATTTTCTGAATAGGCTTCTGGAA  642 GCACTCATGAGAGTGAAACTACAGAAT CD46 chr1 207966775 2.08E+08 2.08E+08 2.08E+08 136 GAGGTTTCTCTAATTTTCCAGTGGTCAA  643 ATGAACAGCAACAACAATAACAAACCAA CD46 chr1 207940336 2.08E+08 2.08E+08 2.08E+08 137 AAATTCTAAGATGTGGAATTGCAAAGTTTGT  644 GCTGTGCACACATACCCTAGAG CD46 chr1 207943522 2.08E+08 2.08E+08 2.08E+08 138 ACAGCCAAACCATATCAAGTGTTTAGAT  645 ATCGGTTTAACCAATTTACAAGCTGAAAAA CD46 chr1 207958318 2.08E+08 2.08E+08 2.08E+08 139 TGAAGACACAGAAATTTTACTAATGCTGTCT  646 CTCTCCAATAAGTGAAAATGGATCTGGT CD46 chr1 207934520 2.08E+08 2.08E+08 2.08E+08 140 CCTACTATGAGATTGGTGAACGAGTAGATT  647 CATCATCACCGTAGTGGAATATGTACC CD46 chr1 207930415 2.08E+08 2.08E+08 2.08E+08 141 GTAATGCAGTCCACCTCACCAT  648 GTGGAGACCAAAGTGATGAACTGT CFI chr4 110681451 1.11E+08 1.11E+08 1.11E+08 142 CTGATAGAAAGTATGGCATACAAATACCCT  649 TGTGCAACTAACAGGAGAAGCTTC CFI chr4 110687639 1.11E+08 1.11E+08 1.11E+08 143 GCAAATACTCCACCAACCTGCTT  650 GCTACAGTAGGGTTATAAATGCAAAGTACT CFI chr4 110682655 1.11E+08 1.11E+08 1.11E+08 144 TTTTTCATTTCAATCAAAGCGATGTCA  651 AGGGAAAAATATAAAAGTGAAGTGTCAGAA CFI chr4 110667496 1.11E+08 1.11E+08 1.11E+08 145 TTGATACCAAAACTACTTGTTGCTTGAAT  652 AGGGAGGATAAGTTTTAAGGCAGAAAATT CFI chr4 110673514 1.11E+08 1.11E+08 1.11E+08 146 TCCTACATGGTAGCTAATCCAGTCAAA  653 CCTTGAAAAATGGAAGGAAATGTGTGAT CFI chr4 110662078 1.11E+08 1.11E+08 1.11E+08 147 CTGAAGAGATAGAAAAGGGCAGATGA  654 CCCAGTATCCGATGTTCAGAACT DGKE chr17  54938979 54939005 54939201 54939224 148 TGTTTCTAGGTTTTTGATGTAACTAAAACTCCT  655 AACAACAACAAAACAACAACAAAACCCATATAT DGKE chr17  54925273 54925306 54925489 54925522 149 AAAACAGTACATGATGAGTGCATGAAAAAT  656 CTATCTCAAACAATGAGTTAAGCAGCTTTT DGKE chr17  54921395 54921425 54921577 54921607 150 GGTGTTCATCACCTTCTGGTGTAG  657 ACCTTGGTGTCATTCTTGAGCA DGKE chr17  54912254 54912278 54912490 54912512 151 ACGTGTGGTTACTTTTGTAGATGGTATT  658 CAGCCAGCTCCCTTGAGATAAG DGKE chr17  54926427 54926455 54926679 54926701 152 CGTGCCCACCTGCTATAGC  659 GGCTGCCGATGTCATTTCCT THBD chr20  23029770 23029789 23029924 23029944 153 GCCATGCTTCCAGGATTAGGAA  660 GGTGTTGTCGCAGCTGTTTTAA CFB chr6  31919590 31919612 31919841 31919863 154 CCTTTTATACCCTGGAAACCCATGA  661 AGGCTCCAGCATTAACAGTTCTG CFB chr6  31915424 31915449 31915676 31915699 155 GGGAAGACGTGAAGTTAGGAATGA  662 GCCATATTTCAGCTTATTCTTGAGCTTG CFB chr6  31918312 31918336 31918510 31918538 156 GGCCCAGAACCTAGCTCTAGAA  663 GAACAGAAGTGGCTTAGGAAGGA CFB chr6  31918810 31918832 31919061 31919084 157 TGCCTGATGCCCTTTATCTTGG  664 AGAAGGACACACGTACTCCAGT CFB chr6  31914025 31914047 31914255 31914277 158 CAGGCTCGCGATGGAGAT  665 CGGTACCTTCGAGTGCATCT THBD chr20  23028563 23028581 23028745 23028765 159 GCAGAGGTAGCTAGTTTGGTTCAG  666 GCAGCGCTGTGTCAACAC THBD chr20  23028977 23029001 23029113 23029131 160 CCCAGGGATCGCATTGCA  667 CGCCGTCTCGATCACCTAC THBD chr20  23029358 23029376 23029562 23029581 161 AATTTCAGCACCACCTGAGCTAA  668 ATGGCTCTTTTAACAGAAATTTCAGTTGG PLG chr6 161143431 1.61E+08 1.61E+08 1.61E+08 162 CTCAAGACAGGGATGACTGGTT  669 GCACAGCTTTCTCCAAAATGATCATTT PLG chr6 161162261 1.61E+08 1.61E+08 1.61E+08 163 TGTCTCGAATTACACCACAAAATTGC  670 TGTGTGGATTTTATGTAAATGTAGAAGGGT PLG chr6 161157849 1.61E+08 1.61E+08 1.61E+08 164 TTCCATATCATCCTGGGTCTCTGT  671 CCAATTCTGTTTGCAAAGATTGGTGAG PLG chr6 161152717 1.61E+08 1.61E+08 1.61E+08 165 GCATCTCCTTCTGCCTTGCTAA  672 CAAATTATTTTACAGGTGAAGGGCAGAA PLG chr6 161133941 1.61E+08 1.61E+08 1.61E+08 166 ATGTGTAAATTGGGATATAATGCAAATACATCA  673 AAGAGTGAGAAGTGGAAAAGTGGAAG CFHR3 chr1 196762550 1.97E+08 1.97E+08 1.97E+08 167 GGCTAGAGTGGGATGAGGAAGAA  674 TGGAGCACTTCAAAATCAGCTGATATTA DGKE chr17  54939745 54939768 54939963 54939991 168 CTTGGACCCTCATCCTTCCTTTT  675 GGTGTAGAGGAAGAATGAATTACTTCAGG CFB chr6  31917163 31917186 31917380 31917409 169 CCCGGTCTCCCTACTACAATGT  676 GGTAGAGAGCAAGAGTTACAGTGTC CFB chr6  31914831 31914853 31915044 31915069 170 ACAGGTGGCAAGTTATGGTGTG  677 GCCCTCAAGGTAGTCTCATGAC CFB chr6  31916146 31916168 31916350 31916372 171 CAGATGTCTTCCTAAGAAATCAAATAAGATACA  678 CACTTTTAGTAGAAAGGAGGTGGTATCAC CFHR3 chr1 196759057 1.97E+08 1.97E+08 1.97E+08 172 TCCACAAGAAAATGTTTGAGAGAAGGT  679 ACCCATTTTGTGTGCAATGAATGTAATC CFHR3 chr1 196748187 1.97E+08 1.97E+08 1.97E+08 173 AGGGTAACTCTACAGAAGTTGCCT  680 CACAGTTAATATAGACAAGTCTGAGACTGT CFHR3 chr1 196748989 1.97E+08 1.97E+08 1.97E+08 174 GGGACATTACTTCATTCCCGTTGT  681 ATCAGACTCATCACACTGATTTTTCCA CFHR1 chr1 196799671 1.97E+08 1.97E+08 1.97E+08 175 GTATTAGTTGATTTGCTACTCAAAATGAACA  682 CCAAACATTTCATAAGGGCTCCTACAT CFHR1 chr1 196797135 1.97E+08 1.97E+08 1.97E+08 176 GGGAAGTTTTCTATTACTCCTGTGAATATAAT  683 TATCCTTCTCTATTCACTGAATGACATCCA CFHR1 chr1 196794690 1.97E+08 1.97E+08 1.97E+08 177 TTGGAAGGTAACATAATCAAAACAGTCATCT  684 AAGTATGGTCTACGCGTATTCTCATAATATAGA CFHR4 chr1 196879318 1.97E+08 1.97E+08 1.97E+08 178 TGTAAACCAGGATATGCAACAGCA  685 CATCTCAAAGAGAGGAACGAAGTTGA CFHR4 chr1 196881961 1.97E+08 1.97E+08 1.97E+08 179 CTATTTTAGGAACATGCTCAAAATCAGATGTAG  686 CATGTAATTGATCCTGAAGAATTTCCCTCT CFHR4 chr1 196874228 1.97E+08 1.97E+08 1.97E+08 180 CGAATACATCAGTTCTATCATTTCAAGCAGT  687 AGAAGCTATCTTTGCAAGCTTTGAGA CFHR4 chr1 196887465 1.97E+08 1.97E+08 1.97E+08 181 CTAAGTGACCTTAAAGCCCTAGCTTT  688 AGACATATGAAGTTAGATATTACACGAAGTTAC CFHR4 chr1 196857141 1.97E+08 1.97E+08 1.97E+08 182 ATGTACATATATATGTAGTCCTCCTATGAGTG  689 CACTTTTAGTAGAAAGGAGGTGGTATCAC CFHR4 chr1 196883890 1.97E+08 1.97E+08 1.97E+08 183 TCCCTCAAGATATTCAATGATCTTTAGCATG  690 GTACTCACCTTTCTTTTCAAATAAAACTACATC PLG chr6 161128625 1.61E+08 1.61E+08 1.61E+08 184 ATTCATTGTAACTTATTTTGCCCATTCAA  691 CAATGGGATTTCACATTCCATAGCAG PLG chr6 161139295 1.61E+08 1.61E+08 1.61E+08 185 GGAATATGGACACAATGAAGTAGTGGAATA  692 TGTATCCACATGTTTTCACTTGTTCTAAGA CFHR5 chr1 196964913 1.97E+08 1.97E+08 1.97E+08 186 CACATTGGACTATGAATGCTATGATGGATA  693 ACTCAAATGAGGACTACATGTATATGTACA CFHR4 chr1 196876060 1.97E+08 1.97E+08 1.97E+08 187 GTGTTTGAGAAATAATTCCTGAACCATCA  694 TGAGAACGTGATGAAAGACGATATCC CFH-V1168X chr1 196716126 1.97E+08 1.97E+08 1.97E+08 188 AGGATATCTGAAGAAAATGAAACAACATGC  695 CCAGAATACAAAGTGACTCTATCATGAACA CFH-C926F chr1 196706723 1.97E+08 1.97E+08 1.97E+08 189 AAACGAAAGAAGAATATGGACACAGTGA  696 ACAGGTACTCTCCTCCACTATGTAAATTTT CFH-E635D chr1 196695656 1.97E+08 1.97E+08 1.97E+08 190 GAACTTTTGTTTGGTTGACTGATTTACCT  697 CGCCATCCAGATTCAGTGCATA CFH-G218E chr1 196648628 1.97E+08 1.97E+08 1.97E+08 191 CTTGAGTAATATGCTCATAAGTTCCTTTCT  698 CCAAGAAGTGACTCCTTGTAAAATGTATTTG PLG chr6 161173793 1.61E+08 1.61E+08 1.61E+08 192 GATCAGGAATAACTTGGTTGGTGAAATTT  699 TATCCATCCTTCTTTTCCTCTACATCTGT Frameshift chr1 196697328 1.97E+08 1.97E+08 1.97E+08 774Stop 193 GGTTTCCTCCCTCCTCAGACA  700 CTGGACTGCTGCAACTACATCA C3-R735W chr19   6706884  6706905  6707137  6707159 194 ATAGACCTGTGACTGTCTAGGCAT  701 GGATATGTTTGGTCAGACCAGGAA CFH chr1 196642002 1.97E+08 1.97E+08 1.97E+08 195 TCAAGAAAGAGAATGCGAACTTCCT  702 CAATGGGAGCCCAAACAAAATTAATAAGAA CFH chr1 196694245 1.97E+08 1.97E+08 1.97E+08 196 AGTTGGTTTGATTCCTATCATTTGAATTTTC  703 CCATTTATGCAGACTGTGTGTATCCAT CFH chr1 196697421 1.97E+08 1.97E+08 1.97E+08 197 TTCCTCCAATCTTATCCTGAGGATGA  704 CGTACTGCTTGTCCAAAATGGT CFH chr1 196646505 1.97E+08 1.97E+08 1.97E+08 198 TTGATGGAGAGTGGACAACTTTACC  705 TCTGTGTCCAATCATTGTAAATGATTCTGA CFH chr1 196695746 1.97E+08 1.97E+08 1.97E+08 199 TACACATGATGTCAGTTTTCAAAGTTTTCC  706 GTATTAGTCCTGAAGATTCAGAATGACCAT CFHR5 chr1 196952984 1.97E+08 1.97E+08 1.97E+08 200 ACATAATGTCTCAACAAATAAATGCTGTTT  707 CAGTTACAGAGCCCTGGAGTTT CFHR5 chr1 196973755 1.97E+08 1.97E+08 1.97E+08 201 AAGAGGTGCAAAATAGCAGGAGTTAATAT  708 AATTTTCTTGTAAAGAAGCAACAAGATCA CFHR5 chr1 196967271 1.97E+08 1.97E+08 1.97E+08 202 GAAAATACAATGTGTGGATGGAGAATGG  709 CAATTCACCTCGACTGAAACTCCA CFHR5 chr1 196964979 1.97E+08 1.97E+08 1.97E+08 203 TCTTATAAGAGTTGGATCAGACTCAGTTCA  710 CTTTGCCATTTTACCACTTTGTCAGATTAT CFHR5 chr1 196963312 1.97E+08 1.97E+08 1.97E+08 204 CCCTTAGTACATTGAAATTCAAAGTCATGC  711 ATTTGTATGCATACACACACACAATCA CFHR5 chr1 196946680 1.97E+08 1.97E+08 1.97E+08 205 CCTGCGTCGGAGAAGACA  712 AAGAGATACACAGGTGCATATGTGG CPAMD1 chr19   6707857  6707875  6707998  6708023 206 CCGTGAGGGCCATGTCTTTC  713 GGGTAACACCTAGAAGAGACTCA CPAMD1 chr19   6690695  6690715  6690838  6690861 207 CTTTGCCTCTCCTAAGCCTGT  714 CACGAGGCCTCTTTGTCTCTC CPAMD1 chr19   6718047  6718068  6718180  6718201 208 GAGCCCTCTCTGAAGGACAAG  715 CCAAGTCCTCGTTGTCCGTT CPAMD1 chr19   6697307  6697328  6697462  6697482 209 GAGAGCAATAACTCCCAAGTGGTT  716 GCAATTTCTCCAGGAATTCCTTATATCTTG CD46 chr1 207940899 2.08E+08 2.08E+08 2.08E+08 210 TTCTCTGTGATGTCATAGTAGCTCCT  717 ACTTCTTCTCCATACTGATAACTGTCTGA CFH chr1 196709623 1.97E+08 1.97E+08 1.97E+08 211 TTTTGGTACTTTTACCCTTACAGGAGG  718 CCATCATAGTTAAACTTTCAGGTACTTGTGTAT CFH chr1 196643017 1.97E+08 1.97E+08 1.97E+08 212 CTCAGTTTACCTAGCTTTGAAAATGCC  719 AAATAAATTTTGAAAATTCACCAAAGTACCTCT CFH chr1 196711015 1.97E+08 1.97E+08 1.97E+08 213 TTATCCAGGTTTTCAGTTACAAATGACTCA  720 TCCCACATGTAATTGATCCTGATGTTTC CFH chr1 196682747 1.97E+08 1.97E+08 1.97E+08 214 AAAACTGTTGATATTATATACAGTGCTGTGT  721 AACTGATGAAGCTGGAGCATATACTG CFH chr1 196714840 1.97E+08 1.97E+08 1.97E+08 215 CCACTGCTCCGTTTCATCCAG  722 GGAGGCTGGAACCCTTTTCAC CPAMD1 chr19   6694493  6694514  6694705  6694726 216 AGGGTTGATTGAGTTTGGATAAAATGAGA  723 CCCTCTACCACCCTGCTAGATG CPAMD1 chr19   6702049  6702078  6702258  6702280 217 GGGCGTGACAATGGTGTG  724 CATCAAGTGCAGAGAAGCCCT CPAMD1 chr19   6678086  6678104  6678231  6678252 218 AGGGCTTAGAAAGGGAGAAGACA  725 GTCACTGTTACTGTCCACGACTT CPAMD1 chr19   6719118  6719141  6719303  6719326 219 GCAGACACGTACAAAGACTTCC  726 CAGAGGATTTCCCTGCCTGAATC CPAMD1 chr19   6713219  6713241  6713433  6713456 220 TACCTAGGCCACTCACAGTCAT  727 GCAGAGAATTGCTTCATACAAAAGTCG CPAMD1 chr19   6678948  6678970  6679196  6679223 221 GGGTGTGTGTTGATGCTGAGTT  728 CAAGACACCCAAGTACTTCAAACC CPAMD1 chr19   6712292  6712314  6712540  6712564 222 CTGAAAGGAAAAGAAAGACCAGCCAGATA  729 CAGGAGCTGGGATAAGTGGAAAG CPAMD1 chr19   6681871  6681900  6682117  6682140 223 GTAGGGCCAAGAGGGCATAGGAT  730 CTTTCTGAGCTTTCTCTGAGCCAT CPAMD1 chr19   6686223  6686246  6686350  6686374 224 CTCCCTCTTGCTTCCCAGTAAA  731 CCATCTTTCTCTCTTGTGGGTTCTAG CPAMD1 chr19   6684917  6684939  6685157  6685183 225 CCTCCAGGCCCTTCTCGTTATA  732 CAGGTCTTCTCCACTGAGTTTGAG CPAMD1 chr19   6714018  6714040  6714189  6714213 226 ACAGTATCAGATACACAGTGTACTTGGA  733 GCCTTATCTGTCACCTTCCTCCTA C3-T1383N chr19   6684280  6684308  6684531  6684555 227 GCAGAGCTTGTTCAGCTTTCCA  734 GAGAATCCCAAAGATCAGAAAGTAGAGG CPAMD1 chr19   6679445  6679467  6679652  6679680 228 GGTCCGTGCTTAAGGATGCTTA  735 CTCTCTCTTCTCTGCAGGGTACA CPAMD1 chr19   6693241  6693263  6693492  6693515 229 GCTGGCACGAGAACCTCATG  736 CAAAGGTGGGAGCCTTTCCTA CPAMD1 chr19   6707206  6707226  6707460  6707481 230 AGCCTGCCCTTGTTCATGATC  737 AGTGCTACGTACAGAGCTCAGA CPAMD1 chr19   6710836  6710857  6711078  6711100 231 GGGATTGTTGCGTCCCATATCT  738 CCGACTGAGGAGAGCTCTAGTC CD46 chr1 207925450 2.08E+08 2.08E+08 2.08E+08 232 CCATTCAAAAGAGCACTGCAGAA  739 TTTACAGGAATGCTTAAGAAGAGAAGCA CD46 chr1 207930796 2.08E+08 2.08E+08 2.08E+08 233 GGGAGGAAGAAGAAAGATTATGACATT  740 CCAACCCAAACTGTCAAGTATTCCT CD46 chr1 207956417 2.08E+08 2.08E+08 2.08E+08 234 AACATTTGACCACTGAAATGTAACCAA  741 AGATAGCATGCAATACAGATTACAAACTGA CD46 chr1 207958855 2.08E+08 2.08E+08 2.08E+08 235 CTTGATGCAGTAACTTATAGTTGTGATCCT  742 ACCTGCTTTGTTTATCTGTAGATGAAACT CD46 chr1 207934667 2.08E+08 2.08E+08 2.08E+08 236 ATGTTCAGGCTGGGTTATTACTAAAATGT  743 CCGAAGAAAACAGAAATAAGGTGCAAT CFI chr4 110678786 1.11E+08 1.11E+08 1.11E+08 237 AGAGGCTAGATTTATGTCTACCTTTACAAC  744 GTCATGCCACCACTCCATAAATAAATTT CFI chr4 110681657 1.11E+08 1.11E+08 1.11E+08 238 CCAAACTCTTTTGTTGACAGTATGTTGG  745 CTTCAAACAGGAGTCTTTAATTTGTTGCT CFI chr4 110687763 1.11E+08 1.11E+08 1.11E+08 239 TCATCCTCATAACAATGCTATGATGCA  746 ACTTGTGGACCAAGATAAGACAATGTT CFI chr4 110685546 1.11E+08 1.11E+08 1.11E+08 240 GTGGTGGGAGGAGATGTTTGATAG  747 ACCCTTTCATAATCCCAATGGTTTAAGTTA CFI chr4 110663574 1.11E+08 1.11E+08 1.11E+08 241 TCAGATATGCTTTATCATCTGCCACAAT  748 GGGAGTCTTGCCATGGAAATATCTT CFI chr4 110670286 1.11E+08 1.11E+08 1.11E+08 242 GCATCTCCATTGTCAAAAGAACACA  749 TGATTTTACTGTACCTTCGGTGATAAGC DGKE chr17  54933767 54933792 54934012 54934041 243 CAATTAGCACAAGCTTTAGCAAAACAA  750 TTCCCAGAGGCAAAACTGCAACT DGKE chr17  54925914 54925941 54926079 54926102 244 CGCTTCCAGTGCAAGGAGATTA  751 ACCACTCTATGAAATCCTGATTCCCA DGKE chr17  54912468 54912490 54912660 54912686 245 CGTCGCCGTTCAGTAGCA  752 CGCCTGGGTAACATGCTTG THBD-D34E chr20  23029906 23029924 23030134 23030153 246 TGCAAACCTTTGTTAGTAACTTTAGTTCG  753 GGATGGCAGGCAACGTCTATAG Q400K chr1 196659029 1.97E+08 1.97E+08 1.97E+08 247 GTCTTTCTGGCTTTCTGTACAATGG  754 CCCTAGTGTCACAGCCAGAGAA PLG chr6 161159492 1.61E+08 1.61E+08 1.61E+08 248 CTGCCCAGCTTGGAAGGTATTAT  755 CTTAACACAGTTGGACCATCAACTTAA DGKE chr17  54939178 54939201 54939403 54939433 249 GCATGGAAAATGTGCTTTTCATCTTTAAG  756 ATCAGGTGATTAGTGACTTGAAGCATTAAT DGKE chr17  54922985 54923014 54923230 54923260 250 ATTTTATGACTATGACGTTGCCCTGAT  757 CTATAAAGGACAAGGAGAACAGCAAACCA CFB chr6  31918483 31918510 31918615 31918644 251 CCCAATCCTTCCTAAGCCACTT  758 AGAAGCTGTAGAGAAAAGGACTGTTG CFB chr6  31919056 31919078 31919292 31919318 252 CCATAGACTCCTACCCAAAAGGCT  759 ACCACCATCTCTTATGGCCATTTTT CFB chr6  31917745 31917769 31917995 31918020 253 GGTTAAAAGATGGCTTGGAAGACCA  760 CAAGTGGACTTAAGGGCCACAT CFB chr6  31916550 31916575 31916789 31916811 254 CTCCTTCCGACTTCTCCAAGAG  761 CTAGTCTCATCCTAGTCCTGACCTT CFB chr6  31914225 31914247 31914440 31914465 255 GGAAAATGGAGAAGGGACAGAACTG  762 GGGAGCTAGTCCTGGAAGATCAG CFB chr6  31915659 31915684 31915900 31915923 256 GAGTCACAGTCGGTGCCAAT  763 CCTGGACGACGGTTTCATCTG THBD chr20  23028696 23028716 23028825 23028846 257 CACTCGAAGCCACCCTGT  764 AGTCCTGCAACGACCTCTG THBD chr20  23029095 23029113 23029266 23029285 258 CGCGGTGCACATTAGCTG  765 GCAGCAGTGCGAAGTGAAG THBD chr20  23029463 23029481 23029658 23029677 259 CCCTGAATATTCTCCCACCTCTT  766 TCGCTTCTGTTCCTGAGCATT PLG chr6 161152031 1.61E+08 1.61E+08 1.61E+08 260 AAGCGTGGTTCCCTAGACTTTTT  767 TGCCACTGGTATACAAAAATAAGGAGAAA PLG chr6 161139661 1.61E+08 1.61E+08 1.61E+08 261 CCGCTGCTCTGTTCTGGAATAT  768 TCTTGATCTTTGCTTACCTGGCAA PLG chr6 161173069 1.61E+08 1.61E+08 1.61E+08 262 ACTCTCTATTTTGCTTCATCCATTTCAGT  769 AAATGACAGCAAATGTCTGATAGAGCT PLG chr6 161135756 1.61E+08 1.61E+08 1.61E+08 263 TCATTAACTTAATTTGACTATCTGGTTTGTGGA  770 AAGTTTCATGAATCAAAAATTAAATGAATTGCA PLG chr6 161123227 1.61E+08 1.61E+08 1.61E+08 264 CTCTGGTTTGCTTCGAGAAGGA  771 AGTTATTTCCAGCATGCTAAATCCCTAC PLG chr6 161173947 1.61E+08 1.61E+08 1.61E+08 265 GGGACTGACTTTTAAACATTATTTGTTCCC  772 CATGTATCTACTTGCGTGAGGATTCTAT DGKE chr17  54939933 54939963 54940177 54940205 266 GTGACAACGGAGGTGAGAAGCA  773 GGTAGGTGACGCTGTCTTCAAG CFB chr6  31914957 31914979 31915186 31915208 267 CATATTGCCATGTTTTTACTTGTTCCCT  774 CAAACATGTAATTGATCCTGAAGAATTTCCATC CFHR3 chr1 196757260 1.97E+08 1.97E+08 1.97E+08 268 GCCTCCTCCACCTATTAGCAATG  775 CACAGTTCTAGGGTAATAACCCATAAAAATTCT CFHR3 chr1 196759193 1.97E+08 1.97E+08 1.97E+08 269 TGAGACTCCTTCAGGAAGTTACTGG  776 AGAGTAATCAATTATGTGCTCTCCTCTCTTTA CFHR3 chr1 196748409 1.97E+08 1.97E+08 1.97E+08 270 TCCTGAACCATCATATAACATTCTACTTGA  777 TGTCCACCTTAATGCTATGTTATAATTTTCCA CFHR1 chr1 196800829 1.97E+08 1.97E+08 1.97E+08 271 AGGACTTTACTAAACTAGCTTCCAGTTAGT  778 AAAAATATGTAAGCATACACACAAAAACCGAT CFHR1 chr1 196788838 1.97E+08 1.97E+08 1.97E+08 272 AATATCCATCTGGTGAGAGAGTACGTTAT  779 TAAATCAACATATTTTAACCCTGCTATACTCCC CFHR1 chr1 196797262 1.97E+08 1.97E+08 1.97E+08 273 AGCCACTTCACCCGGTTTATTAA  780 TTTGTCCTGAAGATTCAGAATGACCA CFHR1 chr1 196795862 1.97E+08 1.97E+08 1.97E+08 274 CACAATATAATTGTAAACCAGGATATGCAACAG  781 CCTCAAAGAGAGGAAAGAAGTTGACAG CFHR4 chr1 196874318 1.97E+08 1.97E+08 1.97E+08 275 GGAAGTCCTCCATAATCATTAGGATGAGA  782 ATCCTGTCCTAACTCAGAATTCAGTTTTATAAC PLG chr6 161128784 1.61E+08 1.61E+08 1.61E+08 276 AGAAGGAAGGAAAAAGAAACACTCCTT  783 GGGACATCACAGTAGTCGTAAAGTTTTC PLG chr6 161154899 1.61E+08 1.61E+08 1.61E+08 277 GCCTCCTCCACCTATTAGCAATG  784 CACAGTTCTAGGGTAATAACCCATAAAAATTCT CFHR4 chr1 196884104 1.97E+08 1.97E+08 1.97E+08 278 TTCAGAAAGTTTCCAATAAAACTGTTGATT  785 CTGGTACTCGACTCTTGACCATG CFHR4 chr1 196876386 1.97E+08 1.97E+08 1.97E+08 279 AATAGTACTCAATTTATTAGCACACACTGA  786 GTAGTCCAATGTGTCATGGAGCTT CFHR4 chr1 196883502 1.97E+08 1.97E+08 1.97E+08 280 TTTATTACAAGAAGTGAAACCTTGTGATTTTCC  787 TCTCTCACTCTTTTCAAGTTTTATGCACA CFHR4 chr1 196871536 1.97E+08 1.97E+08 1.97E+08 281 TGAGTTTCCAGAAATTCAACATGGACA  788 CTCCATTCTTTGCAAGTTTTATGCACA CFHR4 chr1 196879423 1.97E+08 1.97E+08 1.97E+08 282 TATGCACTAGAATCTTGTGATATCCCAGT  789 AGACCAACCATTGTAACCACACA N516K chr1 196684712 1.97E+08 1.97E+08 1.97E+08 283 ATTCGAGAACAGGTGAATCAGTTGAA  790 CGGTCTCAGCTTATAATTACATTTTCACAAATT 3768-71 chr1 196716315 1.97E+08 1.97E+08 1.97E+08 delAGAA 284 ACGCATCATGTGATCCACAAGA  791 TGATATAGACCTCCATGTTTAATGTCTGGAT CFH-C325Y chr1 196658322 1.97E+08 1.97E+08 1.97E+08 285 GGTGGAGGAATATATCTTTGCGAGT  792 CCTCACAAGTATAACTCAATTTAGTCCCA I881L chr1 196706440 1.97E+08 1.97E+08 1.97E+08 286 CATGGGTTATGAATACAGTGAAAGAGGA  793 GAACCTTGAACACAGAAAATGCTATATGTT P258L chr1 196648846 1.97E+08 1.97E+08 1.97E+08 287 AGATAAAAAGAGAGACAGTTGAGAGACAGA  794 GTGGCGTACTACACGCTGAT C3-S562L chr19   6710468  6710498  6710722  6710742 288 GGTCCGTGCTTAAGGATGCTTA  795 CTCTCTCTTCTCTGCAGGGTACA CPAMD1 chr19   6693242  6693264  6693492  6693515 289 GTGGACTTCCCTTCAGTGTATCTC  796 ATTAGGGATTATACAAGAGAAGGTATGTAGGTT PLG chr6 161132093 1.61E+08 1.61E+08 1.61E+08 290 CGCCCTATCCTACCTCACTAAAC  797 GCTAGGGTGATCCTAAGGACAGT CPAMD1 chr19   6696519  6696542  6696745  6696768 291 ATTTAGTTCGGCCTTTAAGATGTCAAAAAC  798 AAAACTTAGAGGCAGGTGCTGAT PLG chr6 161157805 1.61E+08 1.61E+08 1.61E+08 292 CCTACTATGAGATTGGTGAACGAGTAGATT  799 CATCATCACCGTAGTGGAATATGTACC CD46 chr1 207930416 2.08E+08 2.08E+08 2.08E+08 293 TCCCTCAAGATATTCAATGATCTTTAGCATG  800 ATCCTGTCCTAACTCAGAATTCAGTTTTATAAC PLG chr6 161128626 1.61E+08 1.61E+08 1.61E+08 294 GTTTTCGCACTCGTCGATGT  801 CTTCAGAGCCAACTGCGAGTA THBD chr20  23028801 23028821 23029014 23029035 295 CCTGAATAAACTGCAGAACAGAGCT  802 TTTAGCAAGGCAATATCTTTTCGTGTG PLG chr6 161159857 1.61E+08 1.61E+08 1.61E+08 296 GGGTGTATCCAGTCTACTACTGTTG  803 GGGAAATGAAAAAGGTTTTTAAAAGGGAAA CFI chr4 110667602 1.11E+08 1.11E+08 1.11E+08 297 CCCTGATTCTGTCATCCTAGAGAAAC  804 AAAAAGAGCAGTCCAGGTCAGATT PLG chr6 161152674 1.61E+08 1.61E+08 1.61E+08 298 CCCTCCTTATTACTATGGAGATTCAGTG  805 CTGGAAATGTTGAGGCATATCTGTAAATTT CFH chr1 196695952 1.97E+08 1.97E+08 1.97E+08 299 TGCAGGAATCCAGACAACGATC  806 TTACTCAATTATTAATAACATCCCTGTGGGAAG PLG chr6 161134064 1.61E+08 1.61E+08 1.61E+08 300 GGGAGACAGAGCGAAATTTCATCTA  807 CGCGTATTCTCATAATATAGATGTCCATGT CFHR4 chr1 196879257 1.97E+08 1.97E+08 1.97E+08 301 AACATGTTGTAAGGACTCTTTATTCAAGGT  808 CCTCAATCTTATACAAGATTTTCAACTGGAAGT PLG chr6 161123153 1.61E+08 1.61E+08 1.61E+08 302 TGTAGATTGCAATGAACTTCCTCCAA  809 GACTGGCAATAGTGATATAATTCAGGCATA CFH chr1 196642103 1.97E+08 1.97E+08 1.97E+08 303 CCTTTCTGATTTCAATTACTGGGAAAATGT  810 CTTCGTTTGATTACTGCCAGTTATTTCC PLG chr6 161173817 1.61E+08 1.61E+08 1.61E+08 304 TTTTAGAAAGGCCCTGTGGACAT  811 CCCACTCTCCCATAATTATACTCTATCAGA CFH chr1 196642981 1.97E+08 1.97E+08 1.97E+08 305 CTACAGCCAGAAGGCCAAATGGA  812 ACACGCTAAGGAAGAGTTCTCAAAAATTTA CFI chr4 110663521 1.11E+08 1.11E+08 1.11E+08 306 CAAAGACCTTCTTGTTACATATCTCAGTCA  813 ATCCATCTTGTGTGCAATGAATGTG CFH chr1 196658365 1.97E+08 1.97E+08 1.97E+08 307 TAGTGGCACAAATACAATTATGCCCA  814 ACAGAGAAAGAACTTCTCTCTTGTTTACAC CFH chr1 196705951 1.97E+08 1.97E+08 1.97E+08 308 CTGTATGACCCAATATCAACCTCACTT  815 TTACAGGCAATGGGAGCCCAAA CFH chr1 196694148 1.97E+08 1.97E+08 1.97E+08 309 TCATTGTCCACTCCCATAGAAAAGAATC  816 GGTATTCCCGATCTGGTTCCATTG CFH chr1 196646388 1.97E+08 1.97E+08 1.97E+08 310 CAAACCTTTGTTAGTAACTTTAGTTCGTCT  817 ACATGAACATGCTAGGATTTCAGAGTAG CFH chr1 196659032 1.97E+08 1.97E+08 1.97E+08 311 GGTCAAGTCAAAACAGAACTTTTGTTTG  818 GGTAACATTACCTTCACATGAAGGCAA CFH chr1 196648614 1.97E+08 1.97E+08 1.97E+08 312 ATAAGGTACAGATGTAGAGGAAAAGAAGGA  819 ACCTGCCTTATTCAGTAGCATTTGTAATAA CFH chr1 196697568 1.97E+08 1.97E+08 1.97E+08 313 ACCACAGTTACATGTACGGAGAAAG  820 TCTGAGACTGTCGTCCGTGTTA CFHR3 chr1 196749046 1.97E+08 1.97E+08 1.97E+08 314 CCATTAATTCATCCAGGTCTTCACAAGA  821 CCAGAATACAAAGTGACTCTATCATGAACA CFH chr1 196706647 1.97E+08 1.97E+08 1.97E+08 315 GCTACTCAAAATGAACACTAGGTGGAA  822 CAGGAAGAATTGAATTTTAAGCACCATCA CFHR1 chr1 196797150 1.97E+08 1.97E+08 1.97E+08 316 CTGTAATGGCCTGTTTTATTACTAGCATTG  823 TCATTCAGCTTAAACCATGTGAAGTCA CFH chr1 196684418 1.97E+08 1.97E+08 1.97E+08 317 ATTGTAACTTATTTTGCCCATTCAAGCA  824 ACATTCCATAGCAGCAGAATGAGAC PLG chr6 161139300 1.61E+08 1.61E+08 1.61E+08 318 AGTTTCTGATAGGCGGAGCATCTA  825 ACAATGTCAAAAGCCACTCAATTGTC CFH chr1 196621107 1.97E+08 1.97E+08 1.97E+08 319 GTGTTTGAGAAATAATTCCTGAACCATCA  826 TAATACTAAAGTTCTGAATAAAGGTGTGCACTT CFH chr1 196716127 1.97E+08 1.97E+08 1.97E+08 320 TCTACTATAGAGCAAGTACAATCATGTGGT  827 ACAGGTACTCTCCTCCACTATGTAAATTTT CFH chr1 196695590 1.97E+08 1.97E+08 1.97E+08 321 TGCTACGGCTACCAATATTTCTTCAG  828 ACATTACTGGCTCCATCCATTTTGTA CFH chr1 196710764 1.97E+08 1.97E+08 1.97E+08 322 ATGTCTTTGGCAACTCTGAGCT  829 TAAATTACTTACTAATGCACGTGGGTTGA CFH chr1 196682691 1.97E+08 1.97E+08 1.97E+08 323 TTGTAACTGTTATCAGTTGATTTGCTACTCA  830 CACCATCAGTCATTTTATTTGCATTTGAAAAAT CFH chr1 196712509 1.97E+08 1.97E+08 1.97E+08 324 TGAAGTTATATGTGATGAGAACATTGCCA  831 CGTGATTTCATCTCCAGTTCTGTGT CFH chr1 196653903 1.97E+08 1.97E+08 1.97E+08 325 CTCCGAGACCAGGAGGGATACA  832 GGTAGAGAGCAAGAGTTACAGTGTC CFB chr6  31914709 31914731 31915044 31915069 326 TGCTCTTTCCTCACTTTGTTTAAACCT  833 ACGATCTTCCGCTTCTGTTGTT CFB chr6  31915372 31915399 31915724 31915746 327 AGGCTATGACAAAGTCAAGGACATC  834 CTTGACACACGCAGGCAAGACA CFB chr6  31919153 31919178 31919505 31919527 328 GGGAAGACGTGAAGTTAGGAATGA  835 CTATAAAGGACAAGGAGAACAGCAAACCA CFB chr6  31918313 31918337 31918615 31918644 329 TGAGAGGGAGGTGCAATAGGAA  836 GGGCATATTGAGCATCTCTCTCA CFB chr6  31918777 31918799 31919128 31919151 330 GGAATTCTTCCTAAGCCCTGTGAT  837 GCCAAAGCATTGATGTTCACTTGG CFB chr6  31916887 31916911 31917230 31917254 331 GACTGGTAATTCCTCCATGAACCT  838 CGCCCTCAAGGTAGTCTCATGA CFB chr6  31916015 31916039 31916351 31916373 332 TTCTCCTAACACGAGGAAACAAATACC  839 ACAACAGTAGAGAGGGAAAGCTCA CFB chr6  31917682 31917709 31918030 31918054 333 TTGGACACTGAGCCAAGCAGACA  840 GTAGAAGCCAGAAGGACACACGTACT CFB chr6  31913912 31913935 31914260 31914286 334 AGAGTGAAAGTTTATCACACTGAGAAAAGG  841 AGCTAGACATCCTACAATTCAAGGTAAATC CFI chr4 110678740 1.11E+08 1.11E+08 1.11E+08 335 CTTGGCATGCTGTGCAAACATA  842 GACTCCATTATCCCAAAAATCTGATAAGGA CFI chr4 110681528 1.11E+08 1.11E+08 1.11E+08 336 AGAATGACTTGAAAACTAGTCTCTTGCTAC  843 CAAACAGGAGTCTTTAATTTGTTGCTAAGT CFI chr4 110687680 1.11E+08 1.11E+08 1.11E+08 337 TACACAGAAAGGTTAGGTAATCAAAAAGCA  844 GTTCAAAGCTCACTTGACATTAAGTACATT CFI chr4 110685612 1.11E+08 1.11E+08 1.11E+08 338 TAGCGATACAAACAGCCCTAAGATATTTC  845 AATTTACTAATGATTCCAGCCTGTCTTGT CFI chr4 110670518 1.11E+08 1.11E+08 1.11E+08 339 AAAAACAACGTTGAAAATGCAGATGT  846 ATCAAACTTATTACTCTGATTTTCTCAGGATC CFHR3 chr1 196759039 1.97E+08 1.97E+08 1.97E+08 340 CACAAGAAAATGTTTGAGAGAAGGTGA  847 GAGTAATCAATTATGTGCTCTCCTCTCTTT CFHR3 chr1 196748190 1.97E+08 1.97E+08 1.97E+08 341 TGATGTTTACCACAAAGGACTTTACTAAACT  848 CTGCTAATTGCATGTTAGAAAGTATTTCCATAA CFHR1 chr1 196788824 1.97E+08 1.97E+08 1.97E+08 342 TTCTTCAGTTTTATGTTATTTTCCCAGCAAC  849 CTGGCATATCCTTCTCTATTCACTGAATG CFHR1 chr1 196794580 1.97E+08 1.97E+08 1.97E+08 343 ACATAGTCGGTTTGGACAGTGTTT  850 CTAAAGTTCTGAATAAAGGTGTGCATTTTATGA CFHR1 chr1 196800795 1.97E+08 1.97E+08 1.97E+08 344 TCAGTCAATAAATCACTCCCGCATT  851 CAAAGTGGCCAATTATTTTGACTGGAT CFI chr4 110661788 1.11E+08 1.11E+08 1.11E+08 345 GCTCTTGGCCAATATATATTCAAATGGG  852 GTGTAAAGGGTGTAAAGGAGGCAA CD46 chr1 207932774 2.08E+08 2.08E+08 2.08E+08 346 CCAGGTTGGTGGCTCATTACTA  853 CCTACATTCAAGCCACATTGCAATATTAG CD46 chr1 207966742 2.08E+08 2.08E+08 2.08E+08 347 CAGAATGTTGTCACAGAAAATGTGAGT  854 ATCCTATGTTTGGGCACCTCATAAAA CD46 chr1 207956390 2.08E+08 2.08E+08 2.08E+08 348 AGCACTGGATGCTTTGTGAGTT  855 CCGACTGAGGAGAGCTCTAGTC CD46 chr1 207925428 2.08E+08 2.08E+08 2.08E+08 349 TGTTTTTAACATCTTGCATTCCATTCCTTG  856 ATGAACAGCAACAACAATAACAAACCA CD46 chr1 207940239 2.08E+08 2.08E+08 2.08E+08 350 GATTTAGATAGCAAAGAGTCTGGATGGA  857 AATGCAATTGGTAGGACAAACTAATGC CD46 chr1 207958804 2.08E+08 2.08E+08 2.08E+08 351 TCCTAGTGCTGCCTCCATCTAG  858 GCTATACAAATGTCCTCCCTCCTTT CD46 chr1 207940946 2.08E+08 2.08E+08 2.08E+08 352 CTGAATGGTAAAATAAGCGCCTTCAT  859 CTGGAAAGTATAGTCTACGCAAACTCTT CFHR4 chr1 196871251 1.97E+08 1.97E+08 1.97E+08 353 AATTCATTAACAAATGTTTCATTGTTTTGCC  860 AAGTAAAACACTATCATCTCAAAGAGAGGAAC CFHR4 chr1 196881755 1.97E+08 1.97E+08 1.97E+08 354 AAAAACAACGTTGAAAATGCAGATGT  861 ATCAAACTTATTACTCTGATTTTCTCAGGATC CFHR4 chr1 196883950 1.97E+08 1.97E+08 1.97E+08 355 ACATGTAGTCCTCATTTGAGTGTGAATT  862 GACTCTTGACCATGGCAGATACA CFHR4 chr1 196876270 1.97E+08 1.97E+08 1.97E+08 356 GTTTCATTGTTTCACCATACTGCCAT  863 GTAAAACACTATCACCTCAAAGAGAGGAAA CFHR4 chr1 196874138 1.97E+08 1.97E+08 1.97E+08 357 GAGAATTCAAAAACCTAATCATTCCACCAA  864 CTATCTCAAACAATGAGTTAAGCAGCTTTT DGKE chr17  54921454 54921484 54921577 54921607 358 CAGTTACTGTATGGTTTGCAAGCA  865 ACCACTCTATGAAATCCTGATTCCCA DGKE chr17  54912561 54912585 54912660 54912686 359 GCGTGGTCTTGAGATGAGGT  866 GGAGGCTGGAACCCTTTTCAC CPAMD1 chr19   6694354  6694374  6694705  6694726 360 AGGGCTTAGAAAGGGAGAAGACA  867 CGTCTCACATCCGTGGAATGAC CPAMD1 chr19   6719119  6719142  6719443  6719465 361 GGGAGGGATTTACTAGGTGGT  868 GGGTCATTTGGGAAGAGATACAC CPAMD1 chr19   6707680  6707701  6708012  6708035 362 CCTCCATGTAGGTCACCCAATT  869 CAACTGGCCTGCTCTGTTCTAA CPAMD1 chr19   6702334  6702356  6702613  6702635 363 GGTACATTGTCACCACCTGGTA  870 TGCGATCAGAAGAGGTACAGTCA CPAMD1 chr19   6684646  6684668  6684989  6685012 364 GTAGTGTTTCTTCTCCTCCAGCTT  871 CAACTTTCTGCTTGGGAGAGAGA CPAMD1 chr19   6678207  6678231  6678553  6678576 365 GCACCGATCAGCGTGTAGTAC  872 AAGATCCGCTACTACACCTACCT CPAMD1 chr19   6710717  6710738  6710998  6711021 366 CCATCTCCCTGGGTTAGAGACT  873 GAGGGAGGAGGTCTAATCCTGA CPAMD1 chr19   6712323  6712345  6712675  6712697 367 GGGTTAGTCTGACCCAGAGACA  874 GATGACCTGAAGCAGGTATGAAGG CPAMD1 chr19   6681846  6681868  6682143  6682167 368 GCCTCACCTGAGTGCAAGAT  875 ACCTGAAGCCCTCCTTGTCT CPAMD1 chr19   6713193  6713213  6713529  6713549 369 GGCCTCAGTGTCTTCTCTAGGA  876 GCATGCATCTCTTTCTGAGCTTTCT CPAMD1 chr19   6686052  6686074  6686359  6686384 370 GGAGAGCTGCAAATTCCCTGAA  877 ACTAAGAAGTTTGACCTTCCTAGGGTA CPAMD1 chr19   6690539  6690561  6690864  6690891 371 CCTCCAGGCCCTTCTCGTTATA  878 CTTGTCTTGGGACATTCCGGAA CPAMD1 chr19   6714019  6714041  6714370  6714392 372 AGCAAGGACTGTCTGTGTTGTC  879 TCGACCTCAAGGTCACCATAAAAC CPAMD1 chr19   6684237  6684259  6684585  6684609 373 GGTCCATGCTCCTTGGCTAAAG  880 ACATCATCGGGAAGGACACTTG CPAMD1 chr19   6677686  6677708  6678004  6678026 374 GGGTGTGTGTCTGCATATCTCTT  881 CGGGTACCTCTTCATCCAGACA CPAMD1 chr19   6717964  6717987  6718288  6718310 375 GGTGACCTTGTCATCCGACTTT  882 GGGAGGCCCTTATCCTCTCATC CPAMD1 chr19   6679182  6679204  6679529  6679551 376 CAGAAGGCTGGATTGTGGAGTA  883 CGGAGTGGACTAAGAGCTGAGA CPAMD1 chr19   6697533  6697555  6697870  6697892 377 GCAGCTCTGTGATGTAGTTGC  884 AGCTCACGGAGAAGCGAATG CPAMD1 chr19   6707129  6707150  6707483  6707503 378 TCTGAGCTCTGTACGTAGCACT  885 CAATTCCCAGGTCTCAGGGATTC CPAMD1 chr19   6711079  6711101  6711261  6711284 379 GGTCACTGGCCCTTACCTTACT  886 CCAACCTTTCTGTCTTTCCACTCTAG CPAMD1 chr19   6709679  6709701  6709928  6709954 380 TGTTCCTTAGGAATGTGTTCCTTTCC  887 CTTAGACACAATTGGAACCGAAAATCAAAT CFHR5 chr1 196953081 1.97E+08 1.97E+08 1.97E+08 381 GTGGAGGAGGAACCTAGACCAGA  888 GGTGGTATCTCCATTGTTAATAGATGGAG CFHR5 chr1 196973530 1.97E+08 1.97E+08 1.97E+08 382 GTTTTCCACAAAGGGCTTTACTAAACT  889 GCTAATTGCATGTTGGAAAATATTTCCAGA CFHR5 chr1 196946648 1.97E+08 1.97E+08 1.97E+08 383 GTATAGCAATTAAGAGCTCAGGTTCTGA  890 TCCATCGTTTCTCCATTTTAACTGTATGTT CFHR5 chr1 196977316 1.97E+08 1.97E+08 1.97E+08 384 CTTCAGTTTTGTGTTATTTTTCCCAGGAA  891 CCCTTGTGATTATCAAGACCTTATGATCTT CFHR5 chr1 196951989 1.97E+08 1.97E+08 1.97E+08 385 CATTTTCTTAGAACAAGTGAAAACATGTGG  892 CTTGTGGAAGGAAGAGTCAGTATCAATAAA CFHR5 chr1 196965141 1.97E+08 1.97E+08 1.97E+08 386 ACCAACTTAAGAGGTGCAAAATAGCA  893 GCCAAGGCTTTTAAAGAATAACATTTGTCT CFHR5 chr1 196967264 1.97E+08 1.97E+08 1.97E+08 387 CCCAAAAATAGAAGTGCAATATAAAGGCA  894 AAGTGCAAAGTAATAGTAACTGTCCTGT CFHR5 chr1 196964729 1.97E+08 1.97E+08 1.97E+08 388 GAGGCTCATTCTCCTCCCTCTA  895 GCTTGCTCATAGGCATCTCCAT THBD chr20  23028230 23028252 23028573 23028595 389 CGCACATGCACGAGTAGGA  896 CGCCGTCTCGATCACCTAC THBD chr20  23029211 23029230 23029562 23029581 390 CGTGCCCACCTGCTATAGC  897 TTCCTCAATGCCAGTCAGATCTG THBD chr20  23029771 23029790 23029986 23030009 391 GAGCCGAAGTAATAAGTTACACTGAGT  898 GTCCAGCTTGTGAGGTAAGCATAT DGKE chr17  54926373 54926400 54926720 54926744 392 GGGATGAGCTACAATGAATATAAAGAGTC  899 AGAAGTCCTTCTGTAGTAGTTCTTAAAGA DGKE chr17  54925110 54925139 54925433 54925462 393 CCTTTGGTTGCCCTTCTTTTCAT  900 CAAAGTGCCTGGCACACAAATAAA DGKE chr17  54935800 54935823 54936141 54936165 394 GTTTCTTTTCTGGTTAGGTATCGTCCTT  901 GAGCATAATCTCCTTGCACTGGAA DGKE chr17  54912122 54912150 54912471 54912495 395 TTTTTAAGTTGATGGTCCAACTGTGTT  902 CTGTTTCTTCCTCATCCCACTCTAG DGKE chr17  54939401 54939428 54939747 54939772 396 AGTCATAATTCTCAGAGGCTACCGTA  903 GTCTAAGAGAAATTTGGTCCTAGGAAGTTG PLG chr6 161143336 1.61E+08 1.61E+08 1.61E+08 397 CTCAAGACAGGGATGACTGGTT  904 CTTGAAGACTGATTAAGACATAGACAGGT PLG chr6 161162262 1.61E+08 1.61E+08 1.61E+08 398 GCCTTCATCTGATTACCTCCTCCAT  905 ATCCCATAGGACTTGTAGGTCACT PLG chr6 161137543 1.61E+08 1.61E+08 1.61E+08 399 CCCTCACCTGGCTCTTACCT  906 GGTGAAGGAGTACGGTAAGAGGA CPAMD1 chr19   6713961  6713981  6714167  6714190 400 AAATATTTTGGCTCTCTAAGACTTGGCT  907 AGAATGTCGCAGTAGTCATATCTCTTTTC PLG chr6 161133778 1.61E+08 1.61E+08 1.61E+08 401 ACAGCCAAACCATATCAAGTGTTTAGAT  908 ATCGGTTTAACCAATTTACAAGCTGAAAAA CD46 chr1 207958319 2.08E+08 2.08E+08 2.08E+08 402 AATTATTCATTGTAGGGCTGGGCA  909 TGGTAGGTGGGACCAGAAGAT PLG chr6 161138987 1.61E+08 1.61E+08 1.61E+08 403 CTCCTTCCGACTTCTCCAAGAG  910 CTAGTCTCATCCTAGTCCTGACCTT CFB chr6  31914226 31914248 31914440 31914465 404 CTGGTAACAACACCTCTGTGGTA  911 CTAGAAAAATCAGGAATTGGGTGACCTA CPAMD1 chr19   6701995  6702018  6702341  6702369 405 GTGACAGCACCAGAGAATGGAAAAAT  912 TGCTGATATTCCTTAGAATGAACGATGTTT CFH chr1 196646623 1.97E+08 1.97E+08 1.97E+08 406 GCTTTGTCCAGCTCATACTTGG  913 CTCTGTGCTGCTATGTGGGAAT CPAMD1 chr19   6681992  6682014  6682339  6682361 407 GGAGATGCTGTATGCACTGAATCTG  914 GAACCTTGAACACAGAAAATGCTATATGTT CFH chr1 196648872 1.97E+08 1.97E+08 1.97E+08 408 CTCCCTCTTGCTTCCCAGTAAA  915 GTCCCAGCTCTGATTTGAACCT CPAMD1 chr19   6684918  6684940  6685230  6685252 409 CATTGTACTGAGAAATAAAAGGCCTTCCTA  916 GAAGGAAATGTGTGATTTTCTC111CACAT CFI chr4 110662054 1.11E+08 1.11E+08 1.11E+08 410 GGTGCCCGTTTCACGAAG  917 TGAATCCCTTGTCCTCTTGAGAACT CPAMD1 chr19   6693432  6693450  6693683  6693708 411 GTTACAAGCAATGAAACCTTGTGAGTTT  918 TCTTTGCAAGTTTTATGCACATATTGTTGT CFHR4 chr1 196879403 1.97E+08 1.97E+08 1.97E+08 412 GAATGAGAGGCAAGTCGCACTTA  919 TGGGAGGAGGTTAGCTTTGAAATTAAAA PLG chr6 161135712 1.61E+08 1.61E+08 1.61E+08 413 TTGTGATTTTCCAGAAATTCAACATGGAG  920 TCTCTCACTCTTTTCAAGTTTTATGCACAT CFHR4 chr1 196871558 1.97E+08 1.97E+08 1.97E+08 414 GCCCAGGTTTGAAGACAGAGAA  921 CAGAATAGGACCTGGAGATTTTCCTG CFB chr6  31915615 31915637 31915956 31915982 415 GAAAGGTCTTTTGTTTGTCTTTGTCTTGT  922 CCATTCTGGCTGGAATAATACACACA CFH chr1 196670243 1.97E+08 1.97E+08 1.97E+08 416 TGACATTTCCTCTTGTACAACCTTTGT  923 CAGAGCGGTGTACTTACTGACAC CFHR3 chr1 196748752 1.97E+08 1.97E+08 1.97E+08 417 GTAGAATGCTCTCCAGCAATTAAGAGT  924 AGACCAGGAACCTGTCAGAATTTC CFH chr1 196641789 1.97E+08 1.97E+08 1.97E+08 418 GCCATATTGCCATGTTTTACTTGTTC  925 AAGTAAAACACTATCATCTCAAAGAGAGGAAC CFHR3 chr1 196757259 1.97E+08 1.97E+08 1.97E+08 419 GTGTTACTTCTCTGTGATGTCATAGTAGC  926 ATTGGTACCACTTACACTTTGAATGAAGA CFH chr1 196709617 1.97E+08 1.97E+08 1.97E+08 420 AAAAAGTGCTGTTAGATTAAACTGCCA  927 TTTTTGTCTTTACGCATCTGATTAATGGA DGKE chr17  54921171 54921198 54921494 54921523 421 CTACAAGAAAGTCTATGAGAATACAAGCCA  928 GGTTGTCATATTGTGAGAATTGGGAATC CFH chr1 196705704 1.97E+08 1.97E+08 1.97E+08 422 TGAAGACACAGAAATTTTACTAATGCTGTCT  929 CACCTGCTTTGTTTATCTGTAGATGAAACTA CD46 chr1 207934521 2.08E+08 2.08E+08 2.08E+08 423 AGAAACAAGAAACAAGAAAATGCATATGCT  930 ACTAGATTCCCACTCTACATTGTATGAGAA CFH chr1 196644982 1.97E+08 1.97E+08 1.97E+08 424 CTATGAGCACTCAGGTAAAAGCATG  931 GGCAAGAGGAGGTATATAGAAGTATCCTTT CD46 chr1 207930204 2.08E+08 2.08E+08 2.08E+08 425 TGCCCAGCCAATACATCATCAT  932 CCTGTAAGGGTAAAAGTACCAAAAGGA CFH chr1 196642757 1.97E+08 1.97E+08 1.97E+08 426 TTTTTAAAATTTTTATTGCAAGTGAAACCTTGT  933 TCTCCTTTCTTCGATCTTTGAAAGTTTTATACA CFH chr1 196658528 1.97E+08 1.97E+08 1.97E+08 427 ACATAATAGCATTTTGATGCAATGTGATCA  934 GATCCCATCTTCCATTTATGCAGACT CFH chr1 196697304 1.97E+08 1.97E+08 1.97E+08 428 AATCCTTGTGATGAACAAGACATGAATG  935 CCTCACAAGTATAACTCAATTTAGTCCCAT CFH chr1 196706375 1.97E+08 1.97E+08 1.97E+08 429 TCTTGTGATATCCCAGTATTTATGAATGCC  936 CCCAGTTTATGTCAAATCAGGAGATATCTT CFH chr1 196684725 1.97E+08 1.97E+08 1.97E+08 430 CCACATTTGCTAATTGGTTTTCTTGC  937 TTTTTCCTTAACATTCCCATTGAGGAGT CFH chr1 196695341 1.97E+08 1.97E+08 1.97E+08 431 GGGTGAGCAAGTGACTTACACTT  938 CCCACTTCAATCTTCATCTCCCTG CFH chr1 196711078 1.97E+08 1.97E+08 1.97E+08 432 CATCAGGATCAATTACATGTGGGAAAGAT  939 CTGCTTTGTTCCTGCAGGTTTTT CFH chr1 196682991 1.97E+08 1.97E+08 1.97E+08 433 AAACGAAAGAAGAATATGGACACAGTGA  940 CTGTGTCCAATCATTGTAAATGATTCTGAG CFH chr1 196695657 1.97E+08 1.97E+08 1.97E+08 434 TGATATTATATACAGTGCTGTGTTTGCGT  941 CAAACAGTGAAATATCAGACTCATCACAGA CFH chr1 196714849 1.97E+08 1.97E+08 1.97E+08 435 CTTATATTCCAAATGGTGACTACTCACCT  942 GCTTCCAACAGCCTTACTTTGTATATACAA CFH chr1 196654212 1.97E+08 1.97E+08 1.97E+08 436 AGCTGGGTCCCTAGTCTGATTC  943 CCAAAAGGATCTGGAACACAGGT CFB chr6  31919538 31919560 31919860 31919883 437 GCAGGCCAAGATCTCAGTCATT  944 CATTGAGGATGGGTGGAGTGTA CFB chr6  31917903 31917925 31918252 31918274 438 TACATTGGCAAGGATCGCAAAAAC  945 GAGAAGGAGGAATGAAGAAGGCTTT CFB chr6  31917079 31917103 31917428 31917453 439 GCAGGAATTCCTGAATTTTATGACTATGAC  946 CCTAAGCCCTTCTAGAGCTAGGT CFB chr6  31918470 31918500 31918818 31918841 440 GGTGAGAAACGGGCATCCTAAG  947 AACGACTTCTCTTGTGAACTATCAAGG CFB chr6  31919021 31919043 31919346 31919373 441 GCCACTTTGTGGTCAAAGGGAA  948 CCCAACCATGGGTATAGTGTTACA CFB chr6  31916461 31916483 31916809 31916833 442 GCTCCGGACACTGTAACTCTTG  949 AGGTTTAAACAAAGTGAGGAAAGAGCA CFB chr6  31915039 31915061 31915371 31915398 443 TGGGTTCTGAACCAACTCAATGG  950 AGGGACAAAGTTTTTAAATAACGGAACATG CFI chr4 110687377 1.11E+08 1.11E+08 1.11E+08 444 GGCAACGAGGCATCAATCATTT  951 AGAGAATGAGAGGACATTACTCTAGTTTCT CFI chr4 110682579 1.11E+08 1.11E+08 1.11E+08 445 CCTAAAGAAAAGTTTCAGAATCCCTGGAT  952 GTGTTGTAAAGGTAGACATAAATCTAGCCT CFI chr4 110681358 1.11E+08 1.11E+08 1.11E+08 446 GTGCTAGGAAATTAGCTCCTATACATTTCT  953 CTGTTATAGAGCCAGTAAAACTCATCGTTA CFI chr4 110667293 1.11E+08 1.11E+08 1.11E+08 447 GGAATTCCAGTCGCGAATACCA  954 GGGCAGGAGGATGATGTAATTATAAGA CFI chr4 110670220 1.11E+08 1.11E+08 1.11E+08 448 AGCAATTCTCAAGAATCATTTAAGCTTGC  955 AAGGGAGGATAAGTTTTAAGGCAGAAAAT CFI chr4 110673430 1.11E+08 1.11E+08 1.11E+08 449 CAAACAGTGCAACTGAAACTTTTGTATTAG  956 TGCCTTTTACACTGTAGAACTTAGAAAACA CFHR3 chr1 196743965 1.97E+08 1.97E+08 1.97E+08 450 GGATGCATTTTATTTGCTCATGAAAGAGA  957 GACCATAAGAGTGAGAAGTGGAAAAGT CFHR3 chr1 196762382 1.97E+08 1.97E+08 1.97E+08 451 AAAGTGCTGTGTTTGTATTTGCCTTAT  958 ATTTTGTTACCAACAGCAAAATATCAGACT CFHR1 chr1 196799543 1.97E+08 1.97E+08 1.97E+08 452 ACTATGTAGATCAGGAAGATTTGCTACTCT  959 TTCCATGGTTTATTTTTGGAAAATCACAAAAT CFHR1 chr1 196794268 1.97E+08 1.97E+08 1.97E+08 453 TGCTACTTCCATCTTGTACATTAATCCG  960 GGACACAATTGGAACTGAAAATCAAATGAA CFHR1 chr1 196795917 1.97E+08 1.97E+08 1.97E+08 454 ATTTGTTGCTGACTATAGAGTGGCAT  961 GCCAAATTCTTTCAGAGTTCAAAAGTACAA CFI chr4 110722926 1.11E+08 1.11E+08 1.11E+08 455 ATTATATTCCCACCCATTCAAAAGAGCA  962 CCTATCTCCATAAAACATCCAAGAGTTGTT CD46 chr1 207930784 2.08E+08 2.08E+08 2.08E+08 456 CTTCTAGCACAAAATTCATGTTTCCAGT  963 TGCCAATATCTCTTTGCTCAGGTT CD46 chr1 207963414 2.08E+08 2.08E+08 2.08E+08 457 CCATTATAAAATACAGAGTGTGGTGAGCA  964 GCTGTGCACACATACCCTAGAG CD46 chr1 207943447 2.08E+08 2.08E+08 2.08E+08 458 GTTATGTACATTGCATGGGTATATGCTTT  965 GTGGAAGAAGTCGACACTGGAA CD46 chr1 207940765 2.08E+08 2.08E+08 2.08E+08 459 ACAATGGGACTTTCTTAGTTGAGTTGT  966 CACACTCATAGGAGGACTACATATATATGTACA CFHR4 chr1 196883551 1.97E+08 1.97E+08 1.97E+08 460 GCATTTTATTTGCTCATGAAAGGCAA  967 AGACCATAAGAGTGAGAAGTGGAAGT CFHR4 chr1 196887277 1.97E+08 1.97E+08 1.97E+08 461 CTAAGTGACCTTAAAGCCCTAGCTTT  968 ACTCTCACAAAATATGCTACTTCTGCTAG CFHR4 chr1 196857142 1.97E+08 1.97E+08 1.97E+08 462 GCAATGGAGATACCACGTCCTT  969 GTCTCTGAACATTCCTGTTTTTAAAAGGAA CFHR4 chr1 196876482 1.97E+08 1.97E+08 1.97E+08 463 AATGGGACTTTCTTAGTCGAGTTGTAC  970 CACACTCAAATGAGGACTACATGTATATGT CFHR4 chr1 196875919 1.97E+08 1.97E+08 1.97E+08 464 GTAGGAAAGGCTCCCACCTTT  971 GGTGCCTCATCCATCTTCTTCTC CPAMD1 chr19   6707460  6707481  6707566  6707589 465 ATCCATGTGTGGTATCTGAAGAAAACA  972 GCTACTTTTAGCATAGATGGATGTTTGAAG CFHR5 chr1 196977617 1.97E+08 1.97E+08 1.97E+08 466 CCGCATGTTCAGGAAATAGAAGTGT  973 TCAAGAGCACAGCTAGCATGTG PLG chr6 161160161 1.61E+08 1.61E+08 1.61E+08 467 CTGTACCGTCTTCCCAGTGATG  974 AGGAATGCCCTTTGACCTCATG CPAMD1 chr19   6712219  6712241  6712518  6712540 468 GCATCCTGAGGCCTCTTTTCTAG  975 GCACCTTGTCGGTAAGGAACAG CPAMD1 chr19   6684432  6684455  6684774  6684796 469 GAGTTTTCATAGTAGGCTCGGATCTT  976 CACCTGGGTCCCTGTTCTTAAC CPAMD1 chr19   6714221  6714247  6714573  6714595 470 GGCACCTCAATGTTGACCATGA  977 ACAGGGAGTTCAAGTCAGAAAAGG CPAMD1 chr19   6718100  6718122  6718389  6718413 471 TTCTCTTCGTCTTGGCATTCGT  978 ACGACTCAGCTTCTTCCCTCT CPAMD1 chr19   6677960  6677982  6678312  6678333 472 TGGGACCTTCATACTACGAATGC  979 TGCTGAATTGCTCATTCATCTTTGC CPAMD1 chr19   6680033  6680056  6680382  6680407 473 CTGAGCCTCCCTCCTTAGACTA  980 CAGAGGATTTCCCTGCCTGAATC CPAMD1 chr19   6713097  6713119  6713433  6713456 474 CTCAGCTTGGCTTAGGGTCATC  981 CAGAAATCCCTGATGCTCAGGAA CPAMD1 chr19   6686637  6686659  6686988  6687011 475 CTGAAGCCACACCATGACAACCA  982 GGTCTGAGCAAGCCACACTTAC CPAMD1 chr19   6679042  6679065  6679367  6679389 476 AAAGAGAGAGGGAAAGAGAGATGTAGAG  983 CACCGACTTCATCCCTTCCTT CPAMD1 chr19   6710429  6710457  6710749  6710770 477 GCCCAATCTTTGCAAAGGGAAT  984 GTTGACATGGCAGTCTCTGGAT CPAMD1 chr19   6692814  6692836  6693132  6693154 478 TGAATCCACAAACACCCAAATGC  985 AGCTTAGGAAATGGTATTGAGAAATCTGG CPAMD1 chr19   6720415  6720438  6720758  6720787 479 GGAAGAGAAAGGTGCGGGTTAA  986 CAGAATGAACAAAACTGTGGCTGTT CPAMD1 chr19   6696289  6696311  6696634  6696659 480 CTCTCTGAAGGACAAGGGTTTGT  987 TTACCGGCAGAACCAAGAGCTCAA CPAMD1 chr19   6697313  6697336  6697663  6697687 481 AGCCTGCCCTTGTTCATGATC  988 CGTGGGCAACTCCAACAATTAC CPAMD1 chr19   6710837  6710858  6711111  6711133 482 CCCTCCTCAGACGGAGGTTT  989 GAGGCGTGCAAGAAGGTCT CPAMD1 chr19   6706870  6706890  6707161  6707180 483 CCCAATTGGAACCCATGTCCAA  990 GTGTTCGTGCTGAATAAGAAGAACA CPAMD1 chr19   6709506  6709528  6709711  6709736 484 TAGCACACATTAAATTTGTTTCTGCAATGA  991 CTTTGCCATTTTACCACTTTGTCAGATTAT CFHR5 chr1 196963146 1.97E+08 1.97E+08 1.97E+08 485 TGAAGATATTGTTTGGTGCTAGAAGAGTT  992 GTATTAGTCCTGAAGATTCAGAATGACCAT CFHR5 chr1 196952818 1.97E+08 1.97E+08 1.97E+08 486 GAATCTTCCATTTTCCTGAAACACTACC  993 GTGCAACAGATTAGTCATAAGTTCTTGTTT CFHR5 chr1 196971523 1.97E+08 1.97E+08 1.97E+08 487 GCTGTTTTCCAGAGTCTACTGCATA  994 GACAGGAAAGATTTTGACTGAATGAAACTT CFHR5 chr1 196973779 1.97E+08 1.97E+08 1.97E+08 488 AGTGAGCCAAGATTTGCGTGAT  995 ACAGAAATCCATGGTGTATTTTTGGAAA CFHR5 chr1 196951740 1.97E+08 1.97E+08 1.97E+08 489 ACCTCCTCAACTCTCCAATGGT  996 GCTGAACATAACCGTACTCGAGTT CFHR5 chr1 196964869 1.97E+08 1.97E+08 1.97E+08 490 TGTAGCTTCCTAAGAACTATCTTTCAGTCA  997 TCTTTCCCAGATAGCTTGAGTAATGTTTTT CFHR5 chr1 196966970 1.97E+08 1.97E+08 1.97E+08 491 GCGCACTTGTACTCCATCTTG  998 CTACATCCTGGACGACGGTTT THBD chr20  23028478 23028499 23028831 23028852 492 GCAGAGGTAGCTAGTTTGGTTCAG  999 TGCGAGCACTTCTGCGTT THBD chr20  23028978 23029002 23029250 23029268 493 CGCGGTGCACATTAGCTG 1000 CAGTGGGTTACGGGAGACAA THBD chr20  23029464 23029482 23029797 23029817 494 GAGCGCACTGTCATTAGGTG 1001 CAGCGGCAAGAAGTGTCTG THBD chr20  23029951 23029971 23030259 23030278 495 GAAAAGTAAATGCAGAAAGCATCTCCA 1002 CCTACACAAAACAGAGCAGGTAAATATTTC DGKE chr17  54933750 54933777 54934091 54934121 496 TGTGAATTCTAAATGGATGTGTGTGGA 1003 CTTTTTAACACAGTTGGACCATCAACTTAA DGKE chr17  54939081 54939108 54939403 54939433 497 AAGCTTTAGCAAAACAACATACAGTTGT 1004 CACATTTCATCTACACAAGTCTTCACTTG DGKE chr17  54925925 54925953 54926270 54926299 498 AAAATGAAATGCATAAGGGTTAAGGGATTG 1005 TTTGGATGAACATGTATCTACTTGCGT DGKE chr17  54939866 54939896 54940188 54940215 499 GGTGTTCATCACCTTCTGGTGT 1006 GTAATCGCAAAGCTTGGGTTGA DGKE chr17  54912255 54912277 54912596 54912618 500 ATTTCAGCAAATTATAGCACCATTGTTCTC 1007 TCCTATGATCAGGTGATTAGTGACTTGAA DGKE chr17  54922953 54922983 54923238 54923267 501 TTCAAAGCCACTTGTTAACACTTTGTTAG 1008 ATGGAAGGTTTCTGCATCAGTGA PLG chr6 161151977 1.61E+08 1.61E+08 1.61E+08 502 TTGGTTAATGCTAACCAAATAGATTAAAAGGA 1009 GCTCCATAAATTTCTCTTTCCTCTTAAATCATT PLG chr6 161127339 1.61E+08 1.61E+08 1.61E+08 503 GCATTTGAATACATGAATCAAAGAATGGCT 1010 AAGGGAATGTCTTACCTAGGTCTGT PLG chr6 161131918 1.61E+08 1.61E+08 1.61E+08 504 TTGCAGTCCTTTCCTTTGGGAA 1011 CCTTCCCTTCTCTCTTATCCAATTGC PLG chr6 161159442 1.61E+08 1.61E+08 1.61E+08 505 AGAAGGAAGGAAAAAGAAACACTCCTT 1012 TCAAGATGCCCATGATGAAGAGTG PLG chr6 161154900 1.61E+08 1.61E+08 1.61E+08 506 TTTTTCCCGTAACGGTTGTTCTC 1013 GACCACAATAGCATTAAACTTACAAAGCT PLG chr6 161139638 1.61E+08 1.61E+08 1.61E+08 507 CCGCTGCTCTGTTCTGGAATAT 1014 CGGTTGAAAATCCTTGAATTTGCCA PLG chr6 161173070 1.61E+08 1.61E+08 1.61E+08 

What is claimed is:
 1. A method for determining a patient's risk for developing atypical hemolytic uremic syndrome (aHUS), the method comprising: (a) detecting a DNA sequence alteration in a group of aHUS genes, the group consisting of: Complement factor H (CFH), Membrane cofactor protein (CD46), Complement factor 1 (CF1), Complement component 3 (C3), Complement factor B (CFB), Complement factor H-related protein 1 (CDHR1), Complement factor H-related protein 3 (CFHR3), Complement factor H-related protein 4 (CFHR4), Complement factor H-related protein 5 (CFHR5), Thrombomodulin (THBD), Plasminogen (PLG), and Diacyl glycerol kinase (DGKE), wherein the DNA sequence alteration is detected by analyzing the DNA sequence of the twelve aHUS genes in a sample, wherein the aHUS genes are analyzed by amplifying the twelve aHUS genes in the sample using a minimum of twenty four sequences selected from the group comprising SEQ ID NO. 1 through SEQ ID NO. 1014; (b) comparing the amplified aHUS genes from step (a) with amplified aHUS sequences from a normal control subject; and (c) determining the patient's risk for developing aHUS, wherein one or more DNA sequence alterations of CFH, CD46, CFI, C3, CFB, CFHR1, CFHR3, CFHR4, CFHR5, THBD, PLG, and DGKE in the sample that are not present in the normal control has a risk of developing aHUS.
 2. The method of claim 1 wherein the aHUS genes comprise aHUS RNA from a sample or aHUS CDNA made from mRNA from the sample.
 3. The method of claim 1, wherein the DNA sequence alteration in the aHUS gene is a mutation.
 4. The method of claim 1, wherein the DNA sequence alteration in the aHUS gene is a deletion.
 5. The method of claim 1, wherein determining the patient's risk for developing aHUS is made within 48 hours of receipt of the sample from the patient.
 6. The method of claim 1, wherein determining the patient's risk for developing aHUS is made within 5 days of receipt of the sample from the patient. 